Ana Madalena Ludovice

Professor Auxiliar (c/ Nomeação definitiva)
212; 2º piso; Ed. Departamental
(+351) 21 294 85 30

Interesses Científicos

Regulatory networks on cell wall physiology in the methicillin-resistant Staphylococcus aureus (MRSA) strains that hold one of the most effective resistance mechanism to all beta-lactam antibiotics.

Publicações Representativas


Leisico F., D. Vieira, T.A. Figueiredo, M. Silva, E.J. Cabrita, R.G. Sobral, A.M. Ludovice, J. Trincão, M.J. Romão, H. de Lencastre and T. Santos-Silva. First insights of peptidoglycan amidation in Gram-positive bacteria - the high-resolution crystal structure of Staphylococcus aureus glutamine amidotransferase GatD. Scientific Reports. 2018. https://doi.org/10.1038/s41598-018-22986-3.

Figueiredo, T.F., A.M. Ludovice and R.G. Sobral. 2014. Contribution of Peptidoglycan Amidation to Beta-Lactam and Lysozyme Resistance in Different Genetic Lineages of Staphylococcus aureus. 2014
. Microbial Drug Resist. 20(3):238-249. DOI: 10. 1089/mdr.2014.0042 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050451/pdf/mdr.2014.0042.pdf

Vieira V., T.A. Figueiredo, A. Verma, R.G. Sobral, Ludovice A.M., H. de Lencastre and J. Trincão. 2014. Purification, crystallization and preliminary X-ray diffraction analysis of GatD, a glutamine amidotransferase - like protein from Staphylococcus  aureus peptidoglycan. Acta Crystallographica Section F. 70(Pt 5):632-5. doi: 10.1107/S2053230X14007298. http://www.itqb.unl.pt/~nfaria/RSobral_2014/Vieira_2014_ActaF.pdf

Grilo, I.G., A.M. Ludovice, A. Tomasz, H. De Lencastre and R.G. Sobral. 2014. The glucosaminidase domain of Atl the major Staphylococcus aureus autolysin has DNA-binding activity. MicrobiologyOpen. 3(2):247-56. DOI - 10.1002/mbo3.165. http://onlinelibrary.wiley.com/store/10.1002/mbo3.165/asset/mbo3165.pdf?v=1&t=hwvwr570&s=868e74d56aec1351e5afa011ee20ad4715a1e1c1

Figueiredo, T.A., R. G. Sobral, A. M. Ludovice, J. M. F. de Almeida, N. K. Bui, W. Vollmer4, H. de Lencastreand A. Tomasz. 2012. Identification of Genetic Determinants and Enzymes Involved with the Amidation of Glutamic Acid Residues in the Peptidoglycan of Staphylococcus aureus. 2012. PLoS Pathog. 8(1):e1002508. DOI: 10.1371/journal.ppat.1002508