Pedro Viana Baptista

Professor Associado com Agregação

(+351) 21 294 8530 11105

Áreas de Investigação

Nanomedicine & Nanotheranostics - nanotechnology based molecular diagnostics and gene therapy
> gene expression
> biosensors for mutation detection: microfluidics
> (Gold and silver) nanoparticles for DNA/RNA detection and characterisation (mutations, gene expression)
> Gold nanoparticles for cancer therapy - gene delivery; gene silencing
> targeted delivery of drugs

Publicações Representativas

More information Nanomedicine@FCT


Raquel Vinhas, Cláudia Correia, Patricia Ribeiro, Alexandra Lourenço, Aida Botelho de Sousa, Alexandra R. Fernandes, Pedro V. Baptista*. Colorimetric Assessment of BCR-ABL1 Transcripts in Clinical Samples via Gold Nanoprobes. Anal Bioanal. Chem., (2016) 408(19), 5277-5284 doi:10.1007/s00216-016-9622-9 (IF=3.44);

Catarina Roma-Rodrigues, Amelie Heuer-Jungemann, Alexandra R. Fernandes, Antonios G. Kanaras and Pedro V. Baptista*. Peptide coated gold nanoparticles for in vivo modulation of angiogenesis. Int. J. Nanomed., (2016) 11:2633–2639 doi: 10.2147/IJN.S108661 (IF=4.383);

Mílton Cordeiro, Letícia Giestas, João C. Lima and Pedro Baptista*. BioCode Gold-Nanobeacon for the detection of fusion transcripts causing chronic myeloid leukemia. J. Nanobiotechnol., (2016) 14:38 doi:10.1186/s12951-016-0192-y (IF=4.12);

LR Raposo, C Roma‐Rodrigues, P Faísca, M Alves, J Henriques, MC Carvalheiro, ML Corvo, PV Baptista, AJ Pombeiro, AR Fernandes. Immortalization and characterization of a new canine mammary tumour cell line FR37‐CMT. Vet. Comp. Oncol., (2016) doi: 10.1111/vco.12235 (IF=2.733);

Pedro V. Baptista*. Editorial: Precision nanomedicine in cancer: how far are we from personalization? Expert Rev. Precision Medicine and Drug Development, (2016) doi:10.1080/23808993.2016.1174063;

Luisa Corvo, Ana Soraia Mendo, Sara Figueiredo, Miguel Larguinho, Rogério Gaspar, Pedro V. Baptista* and Alexandra R. Fernandes. Liposomes as delivery system of a Sn(IV) compound for cancer therapy. Pharm Res., (2016) 33:1351–1358 doi:10.1007/s11095-016-1876-6 (IF=3.42);

Rita Mendes, Bárbara Carreira, Pedro V. Baptista* and Alexandra R. Fernandes. Non-small cell lung cancer biomarkers and targeted therapy - two faces of the same coin fostered by nanotechnology. Expert Rev. Precision Medicine and Drug Development, (2016) 1: 155-168 doi:10.1080/23808993.2016.1159914;

Zhen Ma, Bian Zhang, M. Fátima C. Guedes da Silva, Ana Soraia Mendo, Joana Silva, P. V. Baptista, Alexandra R. Fernandes, Armando J.L. Pombeiro. Synthesis, Characterization, Thermal Properties and Antiproliferative Potential of Copper(II) 4′-phenyl-terpyridine Compounds. Dalton Trans., (2016) 45(12): 5339-5355 (IF= 4.197);

J Conde, F Tian, JM de la Fuente, PV Baptista. Editorial: Cancer Nanotheranostics: What Have We Learned So Far? Frontiers in Chemistry (2016) 3, 71;

Marta Martins, Pedro V. Baptista, Ana Soraia Mendo, Claudia Correia, Paula Videira, António S. Rodrigues, J. Muthukumaran, Teresa Santos-Silva, Ana Silva, M. Fátima C. Guedes da Silva, Joana Gigante, António Duarte, Armando J. L. Pombeiro, Alexandra R. Fernandes. In vitro and in vivo biological characterization of the anti-proliferative potential of a cyclic trinuclear organotin(IV) complex. Mol. Biosyst., (2016) 12(3): 1015-1023 (IF=3.21);

João Conde, Alfredo Ambrosone, Yulán Hernandez, Furong Tian, Mark MacCully, Catherine C. Berry, Pedro V. Baptista, Claudia Tortiglione, Jesus M. de la Fuente. 15 years on siRNA delivery: beyond the State-of-the-Art on inorganic nanoparticles for RNAi therapeutics. Nano Today, (2015) 10(4): 421-450 doi:10.1016/j.nantod.2015.06.008 (IF=15.000);

Pedro Pedrosa, Raquel Vinhas, Alexandra Fernandes, Pedro V. Baptista*. Nanotheranostics: proof-of-concept or clinical tool? Nanomaterials, (2015) 5: 1853-1879 doi:10.3390/nano5041853 (IF=2.076);

M. McCully, Yulan Hernandez, João Conde, Pedro V. Baptista, Jesus M. de la Fuente, Andrew Hursthouse, David Stirling, C.C. Berry. The significance of the balance between intracellular glutathione and polyethylene glycol (PEG) for successful siRNA release from gold nanoparticles. Nano Research, (2015) 8(10): 3281-3292 doi:10.1007/s12274-015-0828-5 (IF=6.963);

Hannah Child, Yulán Hernandez, João Conde, Margaret Mullin, Pedro Baptista, Jesus Maria de la Fuente, Catherine Cecilia Berry. Gold nanoparticle-siRNA mediated oncogene knockdown: from mRNA through to cell proliferation with off-target effects. Nanomedicine, (2015) 10(16): 2513-2525 doi:10.2217/nnm.15.95 (IF= 5.824);

Pedro Martins, João Jesus, Sofia Santos, Luis R. Raposo, Catarina Roma-Rodrigues, Pedro Viana Baptista* and Alexandra R. Fernandes. Heterocyclic Anticancer Compounds: Recent Advances and the Paradigm Shift towards the Use of Nanomedicine’s Tool Box. Molecules, (2015) 20(9): 16852-16891 doi:10.3390/molecules200916852 (IF=2.416);

Joana Coimbra, Carolina Mota, Sofia Santos, Pedro Viana Baptista and Alexandra R. Fernandes. Inorganic Compounds Going Nano. Ann Med Chem Res., (2015) 1(2): 1010;

Bruno Veigas, Pedro Pedrosa, Fábio F. Carlos, Liliana Mancio-Silva, Ana Rita Grosso, Elvira Fortunato, Maria M. Mota, Pedro V. Baptista*. One nanoprobe, two pathogens: gold nanoprobes multiplexing for point-of-care. J. Nanobiotech., (2015) 13: 48 doi: 10.1186/s12951-015-0109-1 (IF=4.12);

Bruno Veigas, Carla Portugal, Rita Valério, Elvira Fortunato, João G. Crespo, Pedro V. Baptista*. Scalable approach for the production of functional DNA based Gold nanoprobes. J. Membr. Sci., (2015) 492: 528-535 doi: 10.1016/j.memsci.2015.06.042 (IF=4.908);

Raquel Vinhas, Anna Tolmatcheva, Rafaela Canto, Patrícia Ribeiro, Alexandra Lourenço, Aida Botelho de Sousa, Pedro V. Baptista, Alexandra R. Fernandes. A novel mutation in CEBPA gene in a patient with acute myeloid leukemia. Leuk. Lymphoma., (2015) 16: 1-3 doi: 10.3109/10428194.2015.1065979 (IF= 2.605);

João Conde, Furong Tian, Yulan Hernandez, Chenchen Bao, Pedro V. Baptista, Daxiang Cui, Tobias Stoeger and Jesus M de la Fuente. RNAi-based glyconanoparticles trigger apoptotic pathways for in vitro and in vivo enhanced cancer-cell killing. Nanoscale., (2015) 7(19): 9083-91 doi:10.1039/C4NR05742B (IF=6.739);

Bruno Veigas, Elvira Fortunato and Pedro V. Baptista*. Field Effect sensors for nucleic acid detection: Recent advances and future perspectives. Sensors., (2015) 15: 10380-10398 doi:10.3390/s150510380 (IF=2.048);

Ana Mendo, Sara Figueiredo, Catarina Roma-Rodrigues, Paula Videira, Zhen Ma, Mario Diniz, Miguel Larguinho, Pedro Costa, Armando J.L. Pombeiro, Pedro V. Baptista, Alexandra Fernandes. Characterization of antiproliferative potential and biological targets of a copper complex containing 4’-phenyl terpyridine. JBIC., (2015) doi:10.1007/s00775-015-1277-z (IF=3.164);

Rita B. Restani, João Conde, Rita F. Pires, Pedro Martins, Alexandra R. Fernandes, Pedro V. Baptista, Vasco D. B. Bonifácio and Ana Aguiar-Ricardo. POxylated polyurea dendrimers: Smart core-shell vectors with IC50 lowering capacity. Macromol. Biosci., (2015) 1616-5195 doi:10.1002/mabi.201500131 (IF=3.650);

Raquel Vinhas, Milton Cordeiro, Fábio Ferreira Carlos, Soraia Mendo, Alexandra R. Fernandes, Sara Figueiredo, Pedro V. Baptista*. Gold nanoparticle-based theranostics: disease diagnostic and treatment using a single nanomaterial. Nanobiosensors in Disease Diagnosis., (2015) 4:11-23 doi:10.2147/NDD.S60285;

Iwona Bernacka-Wojcik, Hugo Águas, Fabio Ferreira Carlos, Paulo Lopes, Pawel Jerzy Wojcik, Mafalda Nascimento Costa, Bruno Veigas, Rui Igreja, Elvira Fortunato, Pedro Viana Baptista* and Rodrigo Martins. Single nucleotide polymorphism detection using gold nanoprobes and bio-microfluidic platform with embedded microlenses. Biotechnol Bioeng (2015) (Online) doi:10.1002/bit.25542 (IF=4.164);

Pedro V. Baptista*. Gold nanobeacons: a potential nanotheranostics platform. Nanomedicine (Lond). (2014) 9 (15): 2247-2250 doi:10.2217/nnm.14.143 (IF=5.824);

Chenchen Bao, João Conde, Ester Polo, Pablo del Pino, Maria Moros, Pedro V. Baptista, Valeria Grazu, Daxiang Cui, Jesus M de la Fuente. A promising road with challenges: where are gold nanoparticles in translational research? Nanomedicine (Lond.) (2014) 9(15): 2353–2370 doi:10.2217/nnm.14.155 (IF=5.824);

Iwona Bernacka-Wojcik, Susana Ribeiro, Pawel J. Wojcik, Pedro U. Alves, Tito Busani, Elvira Fortunato, Pedro V. Baptista, José A. Covas, Hugo Águas, Loic Hilliou and Rodrigo Martins. Experimental optimization of a passive planar rhombic micromixer with obstacles for effective mixing in a short channel length. RSC Adv. 4(99): 56013-56025 (2014) doi:10.1039/C4RA10160J (IF=3.708);

Rita B. Restani, João Conde,  Pedro V. Baptista, Maria Teresa Cidade, Ana M. Bragança, Jorge Morgado, Ilídio J. Correia, Ana Aguiar-Ricardo and Vasco D. B. Bonifácio. Polyurea dendrimer for efficient cytosolic siRNA delivery. RSC Adv. (2014)  4 (97): 54872-8 doi:10.1039/C4RA09603G (IF=3.708);

Rita M. Cabral and Pedro V. Baptista*. Anti-cancer precision theranostics: a focus on multifunctional gold nanoparticles. Expert Rev. Mol. Diagn. (2014) 14(8):1041-52 doi:10.1586/14737159.2014.965683 (IF=4.270);

Pedro V. Baptista*. Nanodiagnostics: leaving the research lab to enter the clinics? Diagnosis (2014) 1(4):305-9 doi:10.1515/dx-2014-0055;

Pedro Martins, Mara Marques, Lídia Coito, Armando J.L. Pombeiro, Pedro Viana Baptista* and Alexandra R Fernandes. Organometallic Compounds in Cancer Therapy: Past Lessons and Future Directions. Anti-Cancer Agents in Medicinal Chemistry. (2014) 14(9):1199-1212;

Miguel Larguinho, Ana Cordeiro, Mário S. Diniz, Pedro M. Costa, Pedro V. Baptista*. Metabolic and histopathological alterations in the marine bivalve Mytilus galloprovincialis induced by chronic exposure to acrylamide. Environ. Res. (2014) 35: 55–62 doi:10.1016/j.envres.2014.09.004 (IF=3.951);  

Bruno Veigas, Alexandra R. Fernandes, Pedro V. Baptista*. AuNPs for identification of molecular signatures of resistance. Front. Microbiol. (2014) 5:455 doi:10.3389/fmicb.2014.00455 (IF=3.941);

Miguel Larguinho, Sofia Santos, João Almeida, Pedro Baptista*. DNA adduct identification using gold-aptamer nanoprobes.  IET Nanobiotechnol. (2014) doi:10.1049/iet-nbt.2014.0007 (IF= 1.833);

Fábio Ferreira Carlos, Orfeu Flores, Gonçalo Doria, Pedro Viana Baptista*. Characterization of genomic SNP via colorimetric detection using a single gold nanoprobe. Anal. Biochem. (2014) 465: 1-5 doi:10.1016/j.ab.2014.07.019 (IF=2.582);

Miguel Larguinho, Daniela Correia, Mário S. Diniz and Pedro V. Baptista*. Evidence of one-way flow bioaccumulation of gold nanoparticles across two trophic levels. J. Nanopart. Res. (2014) doi:10.1007/s11051-014-2549-1 (IF=2.175);

João Conde, Chenchen Bao, Daxiang Cui, Pedro V. Baptista and Furong Tian. Antibody-Drug gold nanoantennas with Raman spectroscopic fingerprints for in vivo tumour theranostics. J Control Release (2014) 183:87-93 doi:10.1016/j.jconrel.2014.03.045 (IF=7.633);

Madalena M Reimão-Pinto, Ana Cordeiro, Carina Almeida, André Vidal-Pinheiro, Artur Jorge Carneiro Moro, Joao Carlos Lima and Pedro V Baptista*. Dual-color control of nucleotide polymerization sensed by fluorescence actuator. Photochem. Photobiol. Sci. (2014) 13(5):751-756 doi:10.1039/C3PP50438G (IF=2.923);

Pedro Pedrosa, Bruno Veigas, Diana Machado, Isabel Couto, Miguel Viveiros, Pedro V. Baptista*. Gold nanoprobes for multi loci assessment of multi-drug resistant tuberculosis. Tuberculosis (2014) 94:332-337 doi: 10.1016/ (IF=3.036);

João Conde, Miguel Larguinho, Ana Cordeiro, Luis R Raposo, Pedro M Costa, Susana Santos, Mário Diniz, Alexandra R Fernandes, Pedro Viana Baptista*. Gold-Nanobeacons for gene therapy: evaluation of genotoxicity, cell toxicity and proteome profiling analysis. Nanotoxicology (2014) 8(5):521–532 doi: 10.3109/17435390.2013.802821 (IF=7.844);

Pedro Quaresma, Inês Osório, Gonçalo Doria, Patrícia A. Carvalho, Andre M Pereira,   Judith Langer, Joao P Araujo, Isobel Pastoriza-Santos, Luis M. Liz-Marzán,   Ricardo Franco, Pedro V Baptista and Eulália Pereira. Star-shaped magnetite@ gold nanoparticles for protein magnetic separation and SERS detection. RSC Adv., (2014) 4(8):3659–67 doi:10.1039/C3RA46762G (IF=2.562);

Bruno Veigas, Rita Branquinho, Joana V. Pinto, Pawel J. Wojcik, Rodrigo Martins, Elvira Fortunato, Pedro V. Baptista*. Ion sensing (EIS) real-time quantitative monitorization of isothermal DNA amplification. Biosens Bioelectron, (2014) 52: 50–55  doi:10.1016/j.bios.2013.08.029 (IF=5.602);

Bruno Veigas, Pedro Pedrosa, Isabel Couto, Miguel Viveiros, Pedro V. Baptista*. Isothermal DNA amplification coupled to Au-nanoprobes for detection of mutations associated to Rifampicin resistance in Mycobacterium tuberculosis. J Nanobiotechnol. (2013) 11:38 doi:10.1186/1477-3155-11-38;

Conde J, Tian F, Hernández Y, Bao C, Cui D, Janssen KP, Ibarra MR, Baptista PV, Stoeger T, de la Fuente JM. In vivo tumor targeting via nanoparticle-mediated therapeutic siRNA coupled to inflammatory response in lung cancer mouse models. Biomaterials (2013) 34(31):7744-53 doi:10.1016/j.biomaterials.2013.06.041 (IF=7.604)

Iwona Bernacka-Wojcik, Paulo Lopes, Ana Catarina Vaz, Bruno Veigas, Pawel Jerzy Wojcik, Pedro Simões, David Barata, Elvira Fortunato a, Pedro V. Baptista*, Hugo Águas, Rodrigo Martins. Bio-microfluidic platform for gold nanoprobe based DNA detection—application to Mycobacterium tuberculosis. Biosens Bioelectron, (2013) 48:87–93

João Conde, João Rosa, Jesús M. de la Fuente, Pedro V. Baptista*. Gold-nanobeacons for simultaneous gene specific silencing and intracellular tracking of the silencing events. Biomaterials (2013) 34: 2516-2523 (IF=7.404)

Miguel Larguinho, José L. Capelo, Pedro V. Baptista*. Nucleotide identification using gold nanoparticle-based surface assisted laser desorption/ionisation. Talanta, (2013) 105: 417-421 doi: 10.1016/j.talanta.2012.10.072

Veigas B, Jacob JM, Costa MN, Santos DS, Viveiros M, Inácio J, Martins R, Barquinha P, Fortunato E, Baptista PV*. Gold on paper-paper platform for Au-nanoprobe TB detection. Lab Chip. (2012) 12(22):4802-8 (IF=6.5)

Conde J, Ambrosone A, Sanz V, Hernandez Y, Marchesano V, Tian F, Child H, Berry CC, Ibarra MR, Baptista PV, Tortiglione C, de la Fuente JM. Design of Multifunctional Gold Nanoparticles for In Vitro and In Vivo Gene Silencing. ACS Nano, (2012) 6(9): 8316–8324. doi: 10.1021/nn3030223 (IF=11.421)

Pedro V. Baptista. Could gold nanoprobes be an important tool in cancer diagnostics? Expert. Rev. Mol. Diagn., (2012) 12(6):541-3. (IF=4.859) [Editorial]

Vanesa Sanz, João Conde, Yulán Hernández, Pedro V. Baptista, M.R. Ibarra and Jesús M. de la Fuente. Effect of PEG biofunctional spacers and TAT peptide on dsRNA loading on gold nanoparticles. J. Nanopar. Res., (2012) 14:917 doi:10.1007/s11051-012-0917-2 (IF=3.287)

João Conde, Pedro V. Baptista, Yulan Hernández, Vanesa Sanz, Jesus M. de la Fuente. Plasmid DNA Topology Modifications by Protamine Functionalized Gold Nanoparticles. Nanomedicine, (2012) Epub ahead of print (IF=6.692)

João Rosa, João Conde, Jesus M. de la Fuente, J.C. Lima and Pedro V. Baptista*. Gold-nanobeacons for real-time monitoring of RNA synthesis. Biosens Bioelectron., (2012)  36(1):161-167 (IF=5.602)

Gonçalo Doria, João Conde, Bruno Veigas, Leticia Giestas, Carina Almeida, Maria Assunção, João Rosa and Pedro V. Baptista*. Noble Metal Nanoparticles for Biosensing Applications. Sensors (2012) (IF=1.771)

Pedro V. Baptista*. RNA quantification with gold nanoprobes for cancer diagnostics. Clinics in Laboratory Medicine, (2012) 32:1-13 doi:10.1016/j.cll.2011.09.001 (IF=1.971)

Bassem S. S. Guirgis, Cláudia Sá e Cunha, Inês Gomes, Miguel Cavadas, Isabel Silva, Gonçalo Doria, Gregory L. Blatch, Pedro V. Baptista, Eulália Pereira, Hassan M. E. Azzazy, Maria M. Mota, Miguel Prudêncio, Ricardo Franco. Gold nanoparticle-based fluorescence immunoassay for Malaria antigen detection. Anal. Bioanal. Chem., (2012) 402:1019–1027 doi: 10.1007/s00216-011-5489-y (IF=3.841)

Miguel Larguinho and Pedro V. Baptista*. Gold and silver nanoparticles for clinical diagnostics - from genomics to proteomics. J Proteomics, 75: 2811-2823 (2012) Epub doi: 10.1016/j.jprot.2011.11.007 (IF=5.074)

Baptista PV, Doria G, Quaresma P, Cavadas M, Neves CS, Gomes I, Eaton P, Pereira E and Franco R. Nanoparticles in molecular diagnostics. Prog. Mol. Biol. Transl. Sci., (2011) 104:427-88. doi:10.1016/B978-0-12-416020-0.00011-5

João Conde, Gonçalo Doria and Pedro Baptista*. Noble Metal Nanoparticles Applications in Cancer. J Drug Deliv. (2012):751075. Epub 2011. doi:10.1155/2012/751075

J. P. Rosa, J. C. Lima, P. V. Baptista*. Experimental photophysical characterization of fluorophores on the vicinity of gold nanoparticles - deciphering disputes related to kr determination. Nanotechnology, 22 415202 (2011) doi:10.1088/0957-4484/22/41/415202 (IF=3.979)

Rita Branquinho, Bruno Veigas, J. V. Pinto, R. Martins, Elvira Fortunato, Pedro V. Baptista*. Real-time monitoring of PCR amplification of proto-oncogene c-MYC using a Ta2O5 electrolyte-insulator-semiconductor sensor. Biosens Bioelectron., (2011) 28(1):44-9 doi:10.1016/j.bios.2011.06.039. (IF=5.602)

Letícia Giestas, João Carlos Lima, Pedro V. Baptista*. Coupling single base extension to a spectral codification tool for increased throughput screening. J. Biotechnol., (2011) 154:199-204 doi:10.1016/j.jbiotec.2011.05.012 (IF=3.045)

J. Conde, J.M. de la Fuente, P. V. Baptista*. In vitro transcription and translation inhibition via DNA functionalized gold-nanoparticles. Nanotechnology, 21 505101 (2010) doi:10.1088/0957-4484/21/50/505101(IF=3.979)

Leonardo B. Silva, Bruno Veigas, Gonçalo Doria, Pedro Costa, João Inácio, Rodrigo Martins, Elvira Fortunato, Pedro V. Baptista*. Portable optoelectronic biosensing platform for identification of mycobacteria from the Mycobacterium tuberculosis complex. Biosens Bioelectron., (2010) 26(5):2012-7 doi: 10.1016/j.bios.2010.08.078 (IF=5.602)

Bruno Veigas, Diana Machado, João Perdigão, Isabel Portugal, Isabel Couto, Miguel Viveiros, Pedro V. Baptista*. Au-nanoprobes for detection of SNPs associated with antibiotic resistance in Mycobacterium tuberculosis. Nanotechnology, 21: 415101 (2010) doi: 10.1088/0957-4484/21/41/415101 (IF=3.979)