Faculdade

Departamento

Pedro Viana Baptista

Professor Catedrático
308
(+351) 21 294 8530
11105

Interesses Científicos

Nanomedicine & Nanotheranostics - nanotechnology based molecular diagnostics and gene therapy > gene expression > biosensors for mutation detection: microfluidics > (Gold and silver) nanoparticles for DNA/RNA detection and characterisation (mutations, gene expression) > Gold nanoparticles for cancer therapy - gene delivery; gene silencing > targeted delivery of drugs

Publicações Representativas

More information Nanomedicine@FCT

UCIBIO

Mílton Cordeiro, Ana Rita Otrelo-Cardoso, Dmitri I. Svergun, Peter V. Konarev, João C. Lima2, Teresa Santos-Silva and Pedro V. Baptista*. Light encoded DNA biosensor coupled to SAXS based structural interpretation. ACS Chem Bio. (2018) (IF=4.995) (accepted);

A.P.C. Ribeiro, S. Anbu, E.C.B.A. Alegria, A.R. Fernandes, P.V. Baptista*, R. Mendes, A.S. Santos, M. Mendes, M.F.C. Guedes da Silva, A.J.L. Pombeiro. Evaluation of cell toxicity and DNA and protein binding of green synthesized silver nanoparticles. Biomed. Pharmacother., (2018) 101: 137–144 10.1016/j.biopha.2018.02.069 (IF=2.759);

Mark McCully, João Conde, Pedro V. Baptista, Val Olive, Margaret Mullin, Matthew J. Dalby, Catherine C. Berry. Nanoparticle-antagomiR based targeting of miR-31 to accelerate mesenchymal stem cell osteogenic differentiation. PloS one (2018), 13 (2): e0192562 (IF=2.806);

Daniela Peixoto, Margarida Figueiredo, Gabriela Malta, Catarina Roma-Rodrigues, Pedro Baptista, Alexandra Fernandes, Sónia Barroso, Ana Luisa Carvalho, Carlos Afonso, Luisa Ferreira, Paula Branco. Synthesis, cytotoxicity evaluation in human cell lines and in vitro DNA interaction of a hetero arylidene-9(10<i>H</i>)-anthrone. Eur. J. Org. Chem. (2018) 4: 545-549 (IF=2.834);

Pedro Urbano Alves, Raquel Vinhas, Alexandra R. Fernandes, Semra Zuhal Birol, Levent Trabzon, Iwona Bernacka-Wojcik, Rui Igreja, Paulo Lopes, Pedro Viana Baptista*, Hugo Águas, Rodrigo Martins, Elvira Fortunato. Multifunctional microfluidic chip for optical nanoprobe based RNA detection – application to Chronic Myeloid Leukemia. Sci Rep. (2018) 8: 381 doi:10.1038/s41598-017-18725-9 (IF=4.259);

Raquel Vinhas, Rita Mendes, Alexandra R. Fernandes, Pedro V. Baptista*. Nanoparticles – Emerging potential for managing leukemia and lymphoma. Front. Bioeng. Biotechno. – Nanobiotech. (2017), 15 doi: 10.3389/fbioe.2017.00079;

Pedro Pedrosa; Amelie Heuer-Jungemann; Antonios G Kanaras; Alexandra R Fernandes; Pedro V Baptista*. Potentiating angiogenesis arrest in vivo via laser irradiation of peptide functionalised gold nanoparticles.  J. Nanobiotechnol. (2017), 15:85 doi10.1186/s12951-017-0321-2 (IF=4.946);

Beatriz Coelho, Bruno Veigas, Hugo Águas, Elvira Fortunato, Rodrigo Martins, Pedro Viana Baptista* and Rui Igreja. Digital Microfluidics Meets Loop-Mediated Isothermal Amplification. Sensors (2017), 17, 2616; doi:10.3390/s17112616 (IF=2.677);

Ferreira Carlos F, Veigas B, Matias AS, Doria G, Flores O, Baptista PV*. Allele specific LAMP combined to gold nanoparticle characterization of single nucleotide polymorphisms. Biotechnol. Rep. (2017) 17: 25-27 doi.org/10.1016/j.btre.2017.10.003;

Rita Mendes, Pedro Pedrosa, João C. Lima, Alexandra R. Fernandes, Pedro V. Baptista*. Photothermal enhancement of chemotherapy in breast cancer by visible irradiation of Gold Nanoparticles. Sci Rep., (2017) 7: 10872 doi:10.1038/s41598-017-11491-8 (IF=4.259);

Beatriz Coelho, Bruno Veigas, Elvira Fortunato, Rodrigo Martins, Hugo Águas, Rui Igreja, Pedro Viana Baptista*. Digital Microfluidics for nucleic acid amplification. Sensors, (2017) 17(7): 1495 doi:10.3390/s17071495 (IF=2.677);

Raquel Vinhas, Alexandra R. Fernandes, Pedro V. Baptista*. Gold nanoparticles for BCR-ABL1 gene silencing - Improving tyrosine kinase inhibitors efficacy in chronic myeloid leukemia. Mol Ther Nucleic Acids, (2017) 7: 408-416 doi:10.1016/j.omtn.2017.05.003 (IF=5.048);

Rita Mendes, Alexandra Fernandes, Pedro Baptista*.  Gold nanoparticle approach to the selective delivery of gene silencing in cancer – the case for combined delivery? Genes, (2017) 8(3):94 doi:10.3390/genes8030094 (IF=3.600);

Bruno Veigas, Joana Pinto, Raquel Vinhas, Tomás Calmeiro, Rodrigo Martins, Elvira Fortunato and Pedro Viana Baptista*. Quantitative real-time monitoring of RCA amplification of cancer biomarkers mediated by a flexible ion sensitive platform. Biosens. Bioelectron., (2017) 91: 788-795 doi:10.1016/j.bios.2017.01.052 (IF=7.476);

Catarina Roma-Rodrigues, Francisca Pereira, António P. Alves de Matos, Marta Fernandes, Pedro V. Baptista* and Alexandra R. Fernandes. Smuggling gold nanoparticles across cell types – a new role for exosomes in gene silencing. Nanomedicine, (2017) pii: S1549-9634(17)30015-1 doi: 10.1016/j.nano.2017.01.013 (IF=5.671);

L. Raposo, C. Roma-Rodrigues, J. Jesus, L. Martins, A. Pombeiro, P. Baptista, A. Fernandes. Targeting canine mammary tumors via gold nanoparticles functionalized with promising Co(II) and Zn(II) compounds. Vet. Comp. Oncol., (2017) doi:10.1111/vco.12298 (IF=2.452);

Alexandra R. Fernandes, João Jesus, Pedro Martins, Sara Figueiredo, Daniela Rosa, Luísa M.R.D.R.S. Martins, Maria Luísa Corvo, Manuela C. Carvalheiro, Pedro M. Costa, Pedro V. Baptista*. Targeted delivery of chemotherapeutics to lung and colorectal cancer via a gold nanoparticle vectorization system. J. Control. Release (2017) 245: 52–61 doi:10.1016/j.jconrel.2016.11.021 (IF=7.633);

Milton Cordeiro, Lara Carvalho, Joana Silva, Leonor Saúde, Alexandra R. Fernandes and Pedro V. Baptista*. Gold nanobeacons for tracking gene silencing in Zebrafish. Nanomaterials (2017) 7(1), 10 doi:10.3390/nano7010010 (IF=3.553);

Raquel Vinhas, Milton Cordeiro, Pedro Pedrosa, Alexandra R. Fernandes, Pedro V. Baptista*. Current trends in molecular diagnostics of Chronic Myeloid Leukemia. Leuk. Lymphoma., (2016) 1-14 doi:10.1080/10428194.2016.1265116 (IF=2.891);

Milton Cordeiro, Fábio Ferreira Carlos, Pedro Pedrosa, António Lopez, Pedro V. Baptista*. Gold Nanoparticles for diagnostics: Advances towards point-of-care. Diagnostics, (2016) 6(4), pii: E43;

O.A. Lenis-Rojas, A.R Fernandes, C. Roma-Rodrigues, P.V. Baptista, F. Marques, D. Pérez-Fernández, J. Guerra-Varela, L. Sánchez, D. Vázquez-García, M. López Torres, A. Fernández, J.J. Fernández. Heteroleptic mononuclear compounds of ruthenium(II): synthesis, structural analyses, in vitro antitumor activity and in vivo toxicity on zebrafish embryos. Dalton Trans., (2016) doi:10.1039/C6DT03591D (IF=4.177);

Raquel Vinhas, Cláudia Correia, Patricia Ribeiro, Alexandra Lourenço, Aida Botelho de Sousa, Alexandra R. Fernandes, Pedro V. Baptista*. Colorimetric Assessment of BCR-ABL1 Transcripts in Clinical Samples via Gold Nanoprobes. Anal Bioanal. Chem., (2016) 408(19), 5277-5284 doi:10.1007/s00216-016-9622-9 (IF=3.44);

Catarina Roma-Rodrigues, Amelie Heuer-Jungemann, Alexandra R. Fernandes, Antonios G. Kanaras and Pedro V. Baptista*. Peptide coated gold nanoparticles for in vivo modulation of angiogenesis. Int. J. Nanomed., (2016) 11:2633–2639 doi: 10.2147/IJN.S108661 (IF=4.383);

Mílton Cordeiro, Letícia Giestas, João C. Lima and Pedro Baptista*. BioCode Gold-Nanobeacon for the detection of fusion transcripts causing chronic myeloid leukemia. J. Nanobiotechnology., (2016) 14:38 doi:10.1186/s12951-016-0192-y (IF=4.12);

LR Raposo, C Roma‐Rodrigues, P Faísca, M Alves, J Henriques, MC Carvalheiro, ML Corvo, PV Baptista, AJ Pombeiro, AR Fernandes. Immortalization and characterization of a new canine mammary tumour cell line FR37‐CMT. Vet. Comp. Oncol., (2016) doi: 10.1111/vco.12235 (IF=2.733);

Pedro V. Baptista*. Editorial: Precision nanomedicine in cancer: how far are we from personalization? Expert Rev. Precision Medicine and Drug Development, (2016) doi:10.1080/23808993.2016.1174063;

Luisa Corvo, Ana Soraia Mendo, Sara Figueiredo, Miguel Larguinho, Rogério Gaspar, Pedro V. Baptista* and Alexandra R. Fernandes. Liposomes as delivery system of a Sn(IV) compound for cancer therapy. Pharm Res., (2016) 33:1351–1358 doi:10.1007/s11095-016-1876-6 (IF=3.42);

Rita Mendes, Bárbara Carreira, Pedro V. Baptista* and Alexandra R. Fernandes. Non-small cell lung cancer biomarkers and targeted therapy - two faces of the same coin fostered by nanotechnology. Expert Rev. Precision Medicine and Drug Development, (2016) 1: 155-168 doi:10.1080/23808993.2016.1159914;

Zhen Ma, Bian Zhang, M. Fátima C. Guedes da Silva, Ana Soraia Mendo, Joana Silva, P. V. Baptista, Alexandra R. Fernandes, Armando J.L. Pombeiro. Synthesis, Characterization, Thermal Properties and Antiproliferative Potential of Copper(II) 4′-phenyl-terpyridine Compounds. Dalton Trans., (2016) 45(12): 5339-5355 (IF= 4.197);

J Conde, F Tian, JM de la Fuente, PV Baptista. Editorial: Cancer Nanotheranostics: What Have We Learned So Far? Frontiers in Chemistry (2016) 3, 71;

Marta Martins, Pedro V. Baptista, Ana Soraia Mendo, Claudia Correia, Paula Videira, António S. Rodrigues, J. Muthukumaran, Teresa Santos-Silva, Ana Silva, M. Fátima C. Guedes da Silva, Joana Gigante, António Duarte, Armando J. L. Pombeiro, Alexandra R. Fernandes. In vitro and in vivo biological characterization of the anti-proliferative potential of a cyclic trinuclear organotin(IV) complex. Mol. Biosyst., (2016) 12(3): 1015-1023 (IF=3.21);

João Conde, Alfredo Ambrosone, Yulán Hernandez, Furong Tian, Mark MacCully, Catherine C. Berry, Pedro V. Baptista, Claudia Tortiglione, Jesus M. de la Fuente. 15 years on siRNA delivery: beyond the State-of-the-Art on inorganic nanoparticles for RNAi therapeutics. NanoToday, (2015) 10(4): 421-450 doi:10.1016/j.nantod.2015.06.008 (IF=15.000);

C Roma-Rodrigues, C Alves-Barroco, LR Raposo, MN Costa, E Fortunato, Pedro Viana Baptista, Alexandra R Fernandes, Ilda Santos-Sanches. Infection of human keratinocytes by Streptococcus dysgalactiae subspecies dysgalactiae isolated from milk of the bovine udder. Microbes and Infection (2015) S1286-4579(15)00253-1. doi:10.1016/j.micinf.2015.11.005 (IF=2.861);

Larguinho, M, Canto R, Cordeiro M, Pedrosa P, Fortuna A, Vinhas R, Baptista PV*.  Gold nanoprobe-based non-crosslinking hybridization for molecular diagnostics. Expert. Rev. Mol. Diagn., (2015) 15(10): 1355-1368 doi:10.1586/14737159.2015.1077704 (IF=3.516);

Pedro Pedrosa, Raquel Vinhas, Alexandra Fernandes, Pedro V. Baptista*. Nanotheranostics: proof-of-concept or clinical tool? Nanomaterials, (2015) 5: 1853-1879 doi:10.3390/nano5041853 (IF=2.690);

M. McCully, Yulan Hernandez, João Conde, Pedro V. Baptista, Jesus M. de la Fuente, Andrew Hursthouse, David Stirling, C.C. Berry. The significance of the balance between intracellular glutathione and polyethylene glycol (PEG) for successful siRNA release from gold nanoparticles. Nano Research, (2015) 8(10): 3281-3292 doi:10.​1007/​s12274-015-0828-5 (IF=6.963);

Hannah Child, Yulán Hernandez, João Conde, Margaret Mullin, Pedro Baptista, Jesus Maria de la Fuente, Catherine Cecilia Berry. Gold nanoparticle-siRNA mediated oncogene knockdown: from mRNA through to cell proliferation with off-target effects. Nanomedicine, (2015) 10(16): 2513-2525 doi:10.2217/nnm.15.95 (IF= 5.824);

Pedro Martins, João Jesus, Sofia Santos, Luis R. Raposo, Catarina Roma-Rodrigues, Pedro Viana Baptista* and Alexandra R. Fernandes. Heterocyclic Anticancer Compounds: Recent Advances and the Paradigm Shift towards the Use of Nanomedicine’s Tool Box. Molecules, (2015) 20(9): 16852-16891 doi:10.3390/molecules200916852 (IF=2.416);

Joana Coimbra, Carolina Mota, Sofia Santos, Pedro Viana Baptista and Alexandra R. Fernandes. Inorganic Compounds Going Nano. Ann. Med. Chem. Res., (2015) 1(2): 1010;

Bruno Veigas, Pedro Pedrosa, Fábio F. Carlos, Liliana Mancio-Silva, Ana Rita Grosso, Elvira Fortunato, Maria M. Mota, Pedro V. Baptista*. One nanoprobe, two pathogens: gold nanoprobes multiplexing for point-of-care. J. Nanobiotech., (2015) 13: 48 doi:10.1186/s12951-015-0109-1 (IF=4.12);

Bruno Veigas, Carla Portugal, Rita Valério, Elvira Fortunato, João G. Crespo, Pedro V. Baptista*. Scalable approach for the production of functional DNA based Gold nanoprobes. J. Membr. Sci., (2015) 492: 528-535 doi:10.1016/j.memsci.2015.06.042 (IF=4.908);

Raquel Vinhas, Anna Tolmatcheva, Rafaela Canto, Patrícia Ribeiro, Alexandra Lourenço, Aida Botelho de Sousa, Pedro V. Baptista, Alexandra R. Fernandes. A novel mutation in CEBPA gene in a patient with acute myeloid leukemia. Leuk. Lymphoma., (2015) 16: 1-3 doi:10.3109/10428194.2015.1065979 (IF= 2.605);

João Conde, Furong Tian, Yulan Hernandez, Chenchen Bao, Pedro V. Baptista, Daxiang Cui, Tobias Stoeger and Jesus M de la Fuente. RNAi-based glyconanoparticles trigger apoptotic pathways for in vitro and in vivo enhanced cancer-cell killing. Nanoscale., (2015) 7(19): 9083-91 doi:10.1039/C4NR05742B (IF=6.739);

Bruno Veigas, Elvira Fortunato and Pedro V. Baptista*. Field Effect sensors for nucleic acid detection: Recent advances and future perspectives. Sensors., (2015) 15: 10380-10398 doi:10.3390/s150510380 (IF=2.048);

Ana Mendo, Sara Figueiredo, Catarina Roma-Rodrigues, Paula Videira, Zhen Ma, Mario Diniz, Miguel Larguinho, Pedro Costa, Armando J.L. Pombeiro, Pedro V. Baptista, Alexandra Fernandes. Characterization of antiproliferative potential and biological targets of a copper complex containing 4’-phenyl terpyridine. JBIC., (2015) doi:10.1007/s00775-015-1277-z (IF=3.164);

Rita B. Restani, João Conde, Rita F. Pires, Pedro Martins, Alexandra R. Fernandes, Pedro V. Baptista, Vasco D. B. Bonifácio and Ana Aguiar-Ricardo. POxylated polyurea dendrimers: Smart core-shell vectors with IC50 lowering capacity. Macromol. Biosci., (2015) 1616-5195 doi:10.1002/mabi.201500131 (IF=3.650);

Raquel Vinhas, Milton Cordeiro, Fábio Ferreira Carlos, Soraia Mendo, Alexandra R. Fernandes, Sara Figueiredo, Pedro V. Baptista*. Gold nanoparticle-based theranostics: disease diagnostic and treatment using a single nanomaterial. Nanobiosensors in Disease Diagnosis., (2015) 4:11-23 doi:10.2147/NDD.S60285;

Iwona Bernacka-Wojcik, Hugo Águas, Fabio Ferreira Carlos, Paulo Lopes, Pawel Jerzy Wojcik, Mafalda Nascimento Costa, Bruno Veigas, Rui Igreja, Elvira Fortunato, Pedro Viana Baptista* and Rodrigo Martins. Single nucleotide polymorphism detection using gold nanoprobes and bio-microfluidic platform with embedded microlenses. Biotechnol. Bioeng., (2015) (Online) doi:10.1002/bit.25542 (IF=4.164);

Pedro V. Baptista*. Gold nanobeacons: a potential nanotheranostics platform. Nanomedicine (Lond)., (2014) 9 (15): 2247-2250 doi:10.2217/nnm.14.143 (IF=5.824);

Chenchen Bao, João Conde, Ester Polo, Pablo del Pino, Maria Moros, Pedro V. Baptista, Valeria Grazu, Daxiang Cui, Jesus M de la Fuente. A promising road with challenges: where are gold nanoparticles in translational research? Nanomedicine (Lond.), (2014) 9(15): 2353–2370 doi:10.2217/nnm.14.155 (IF=5.824);

Iwona Bernacka-Wojcik, Susana Ribeiro, Pawel J. Wojcik, Pedro U. Alves, Tito Busani, Elvira Fortunato, Pedro V. Baptista, José A. Covas, Hugo Águas, Loic Hilliou and Rodrigo Martins. Experimental optimization of a passive planar rhombic micromixer with obstacles for effective mixing in a short channel length. RSC Adv., 4(99): 56013-56025 (2014) doi:10.1039/C4RA10160J (IF=3.840);

Rita B. Restani, João Conde, Pedro V. Baptista, Maria Teresa Cidade, Ana M. Bragança, Jorge Morgado, Ilídio J. Correia, Ana Aguiar-Ricardo and Vasco D. B. Bonifácio. Polyurea dendrimer for efficient cytosolic siRNA delivery. RSC Adv., (2014) 4(97): 54872-8 doi:10.1039/C4RA09603G (IF=3.840);

Rita M. Cabral and Pedro V. Baptista­*. Anti-cancer precision theranostics: a focus on multifunctional gold nanoparticles. Expert Rev. Mol. Diagn., (2014) 14(8): 1041-52 doi:10.1586/14737159.2014.965683 (IF=4.270);

Pedro V. Baptista*. Nanodiagnostics: leaving the research lab to enter the clinics? Diagnosis, (2014) 1(4): 305-9 doi:10.1515/dx-2014-0055;

Pedro Martins, Mara Marques, Lídia Coito, Armando J.L. Pombeiro, Pedro Viana Baptista* and Alexandra R Fernandes. Organometallic Compounds in Cancer Therapy: Past Lessons and Future Directions. Anti-Cancer Agents in Medicinal Chemistry, (2014) 14(9): 1199-1212 (IF=2.469);

Miguel Larguinho, Ana Cordeiro, Mário S. Diniz, Pedro M. Costa, Pedro V. Baptista*. Metabolic and histopathological alterations in the marine bivalve Mytilus galloprovincialis induced by chronic exposure to acrylamide. Environ. Res., (2014) 35: 55–62 doi:10.1016/j.envres.2014.09.004 (IF=3.951);

Bruno Veigas, Alexandra R. Fernandes, Pedro V. Baptista*. AuNPs for identification of molecular signatures of resistance. Front. Microbiol., (2014) 5:455 doi:10.3389/fmicb.2014.00455 (IF=3.941);

Miguel Larguinho, Sofia Santos, João Almeida, Pedro Baptista*. DNA adduct identification using gold-aptamer nanoprobes. IET Nanobiotechnol., (2014) doi:10.1049/iet-nbt.2014.0007 (IF= 1.833);

Fábio Ferreira Carlos, Orfeu Flores, Gonçalo Doria, Pedro Viana Baptista*. Characterization of genomic SNP via colorimetric detection using a single gold nanoprobe. Anal. Biochem., (2014) 465: 1-5 doi:10.1016/j.ab.2014.07.019 (IF=2.582);

Miguel Larguinho, Daniela Correia, Mário S. Diniz and Pedro V. Baptista*. Evidence of one-way flow bioaccumulation of gold nanoparticles across two trophic levels. J. Nanopart. Res., (2014) 16:2549. doi:10.1007/s11051-014-2549-1 (IF=2.175);

Conde J, Dias JT, Grazú V, Moros M, Baptista PV and de la Fuente JM. Revisiting 30 years of biofunctionalization and surface chemistry of inorganic nanoparticles for nanomedicine. Front. Chem., (2014) 2: 48. doi:10.3389/fchem.2014.0004;

Catarina Roma-Rodrigues, Alexandra R. Fernandes and Pedro Viana Baptista*. Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells. BioMed Research International, (2014) Article ID 179486 doi:10.1155/2014/179486 (IF=2.706);

João Conde, Chenchen Bao, Daxiang Cui, Pedro V. Baptista and Furong Tian. Antibody-Drug gold nanoantennas with Raman spectroscopic fingerprints for in vivo tumour theranostics. J Control Release, (2014) 183: 87-93 doi:10.1016/j.jconrel.2014.03.045 (IF=7.633);

Pedro Martins, Daniela Rosa, Alexandra R. Fernandes and Pedro V. Baptista*. Nanoparticles Drug Delivery Systems: Recent Patents and Applications in Nanomedicine. Recent Patents Nanomed., (2014) 3(2):1 05-118 doi:10.2174/1877912304666140304000133;

Madalena M Reimão-Pinto, Ana Cordeiro, Carina Almeida, André Vidal-Pinheiro, Artur Jorge Carneiro Moro, Joao Carlos Lima and Pedro V Baptista*. Dual-color control of nucleotide polymerization sensed by fluorescence actuator. Photochem. Photobiol. Sci., (2014) 13(5): 751-756 doi:10.1039/C3PP50438G (IF=2.923);

Pedro Pedrosa, Bruno Veigas, Diana Machado, Isabel Couto, Miguel Viveiros, Pedro V. Baptista*. Gold nanoprobes for multi loci assessment of multi-drug resistant tuberculosis. Tuberculosis, (2014) 94: 332-337 doi:10.1016/j.tube.2013.12.009 (IF=3.036);

Daniel Luis, Joana Silva, Ana Tomaz, Rodrigo Almeida, Miguel Larguinho, Pedro Baptista, Luisa Martins, Telma Silva, Pedro Borralho, Cecília Rodrigues, António Rodrigues, Armando J.L. Pombeiro, Alexandra Fernandes. Insights into the mechanisms underlying the anti-proliferative potential of a Co(II) coordination compound bearing 1,10-phenanthroline-5,6-dione: DNA and protein interaction studies. J. Biol. Inorg. Chem., (2014) 19: 787–803 doi:10.1007/s00775-014-1110-0 (IF=3.353);

Costa MN, Veigas B, Jacob JM, Santos DS, Gomes J, Baptista PV, Martins R, Inácio J, Fortunato E. A low cost, safe, disposable, rapid and self-sustainable paper-based platform for diagnostic testing: lab-on-paper. Nanotechnology, (2014) 7:25(9): 094006. doi:10.1088/0957-4484/25/9/094006 (IF=3.979);

João Conde, Miguel Larguinho, Ana Cordeiro, Luis R Raposo, Pedro M Costa, Susana Santos, Mário Diniz, Alexandra R Fernandes, Pedro V. Baptista*. Gold-Nanobeacons for gene therapy: evaluation of genotoxicity, cell toxicity and proteome profiling analysis. Nanotoxicology, (2014) 8(5): 521–532 doi: 10.3109/17435390.2013.802821 (IF=7.844);

Pedro Quaresma, Inês Osório, Gonçalo Doria, Patrícia A. Carvalho, Andre M Pereira, Judith Langer, Joao P Araujo, Isobel Pastoriza-Santos, Luis M. Liz-Marzán, Ricardo Franco, Pedro V. Baptista and Eulália Pereira. Star-shaped magnetite@ gold nanoparticles for protein magnetic separation and SERS detection. RSC Adv., (2014) 4(8): 3659–67 doi:10.1039/C3RA46762G (IF=2.562);

Bruno Veigas, Rita Branquinho, Joana V. Pinto, Pawel J. Wojcik, Rodrigo Martins, Elvira Fortunato, Pedro V. Baptista*. Ion sensing (EIS) real-time quantitative monitorization of isothermal DNA amplification. Biosens. Bioelectron., (2014) 52: 50–55 doi:10.1016/j.bios.2013.08.029 (IF=6.451);

Miguel Larguinho, Pedro M. Costa, Gonçalo Sousa, Maria H. Costa, Mário S. Diniz, Pedro V. Baptista*. Histopathological findings on Carassius auratus hepatopancreas upon exposure to acrylamide: correlation with genotoxicity and metabolic alterations. J. Appl. Toxicol., (2014) 34(12): 1293-302 doi:10.1002/jat.2936 (IF= 3.174);

Alexandra R. Fernandes & Pedro Viana Baptista*. Cancer Nanotechnology: Prospects for Cancer Diagnostics and Therapy – An Update. Curr. Cancer Ther. Rev., (2013) 9: 164-172;

Bruno Veigas, Pedro Pedrosa, Isabel Couto, Miguel Viveiros, Pedro V. Baptista*. Isothermal DNA amplification coupled to Au-nanoprobes for detection of mutations associated to Rifampicin resistance in Mycobacterium tuberculosis. J. Nanobiotechnology., (2013) 11: 38 doi:10.1186/1477-3155-11-38 (IF=4.08);

Conde J, Rosa J, Baptista P*. Gold-Nanobeacons as a theranostic system for the detection and inhibition of specific genes. Protoc. Exch., (2013) doi:10.1038/protex.2013.088;

João Conde, Jesus M. de la Fuente and Pedro V. Baptista. Nanomaterials for reversion of multidrug resistance in cancer: a new hope for an old idea? Front. Pharmacol., (2013) doi:10.3389/fphar.2013.00134;

R. Branquinho, J. V. Pinto, T. Busani, P. Barquinha, L. Pereira, P. V. Baptista, R. Martins, and E. Fortunato. Plastic Compatible Sputtered Ta2O5 Sensitive Layer for Oxide Semiconductor TFT Sensors. J. Display Technol., (2013) 9: 723-728 (IF=1.663);

Cordeiro M, Giestas L, Lima JC, Baptista P*. Coupling an universal primer to SBE combined spectral codification strategy for single nucleotide polymorphism analysis. J. Biotechnol., (2013) 168: 90-4 doi: 10.1016/j.jbiotec.2013.08.005 (IF=3.340);

Carlos FF, Silva-Nunes J, Flores O, Brito M, Doria G, Veiga L, Baptista PV*. Association of FTO and PPARG polymorphisms with obesity in Portuguese women. Diabetes Metab. Syndr. Obes., (2013) 6: 241-5. doi:10.2147/DMSO.S45779;

Conde J, Tian F, Hernández Y, Bao C, Cui D, Janssen KP, Ibarra MR, Baptista PV, Stoeger T, de la Fuente JM. In vivo tumor targeting via nanoparticle-mediated therapeutic siRNA coupled to inflammatory response in lung cancer mouse models. Biomaterials, (2013) 34(31): 7744-53 doi:10.1016/j.biomaterials.2013.06.041 (IF=8.312);

Rita Cabral and Pedro V. Baptista*. The chemistry and biology of gold nanoparticle-mediated photothermal therapy: promises and challenges. Nano LIFE, (2013) 03, 1330001 doi:10.1142/S179398441330001X;

Iwona Bernacka-Wojcik, Paulo Lopes, Ana Catarina Vaz, Bruno Veigas, Pawel Jerzy Wojcik, Pedro Simões, David Barata, Elvira Fortunato, Pedro V. Baptista*, Hugo Águas, Rodrigo Martins. Bio-microfluidic platform for gold nanoprobe based DNA detection—application to Mycobacterium tuberculosis. Biosens. Bioelectron., (2013) 48: 87–93 doi:10.1016/j.bios.2013.03.079 (IF=6.451);

João Conde, João Rosa, Jesús M. de la Fuente, Pedro V. Baptista*. Gold-nanobeacons for simultaneous gene specific silencing and intracellular tracking of the silencing events. Biomaterials, (2013) 34(10): 2516-23 doi:10.1016/j.biomaterials.2012.12.015 (IF=8.312);

Miguel Larguinho, José L. Capelo, Pedro V. Baptista*. Nucleotide identification using gold nanoparticle-based surface assisted laser desorption/ionisation. Talanta, (2013) 105: 417-421 doi: 10.1016/j.talanta.2012.10.072 (IF=3.794);

Veigas B, Jacob JM, Costa MN, Santos DS, Viveiros M, Inácio J, Martins R, Barquinha P, Fortunato E, Baptista PV*. Gold on paper-paper platform for Au-nanoprobe TB detection. Lab Chip., (2012) 12(22): 4802-8 doi:10.1039/C2LC40739F (IF=6.5);

Conde J, Ambrosone A, Sanz V, Hernandez Y, Marchesano V, Tian F, Child H, Berry CC, Ibarra MR, Baptista PV, Tortiglione C, de la Fuente JM. Design of Multifunctional Gold Nanoparticles for In Vitro and In Vivo Gene Silencing. ACS Nano, (2012) 6(9): 8316–8324 doi:10.1021/nn3030223 (IF=11.421);

Pedro V. Baptista*. Could gold nanoprobes be an important tool in cancer diagnostics? Expert Rev. Mol. Diagn., (2012) 12(6): 541-3. (IF=4.859);

Vanesa Sanz, João Conde, Yulán Hernández, Pedro V. Baptista, M.R. Ibarra and Jesús M. de la Fuente. Effect of PEG biofunctional spacers and TAT peptide on dsRNA loading on gold nanoparticles. J. Nanopart. Res., (2012) 14: 917 doi:10.1007/s11051-012-0917-2 (IF=3.287);

Margarida Moreira dos Santos, Margarida João Queiroz, Pedro V. Baptista. Enhancement of antibiotic effect via gold:silver alloy nanoparticles. J. Nanopart. Res., (2012) 14: 859 doi:10.1007/s11051-012-0859-8 (IF=3.287);

João Conde, Pedro V. Baptista, Yulan Hernández, Vanesa Sanz, Jesus M. de la Fuente. Plasmid DNA Topology Modifications by Protamine Functionalized Gold Nanoparticles. Nanomedicine, (2012) 7(11): 1657-66 doi:10.2217/nnm.12.21 (IF=6.692);

João Rosa, João Conde, Jesus M. de la Fuente, J.C. Lima and Pedro V. Baptista*. Gold-nanobeacons for real-time monitoring of RNA synthesis. Biosens Bioelectron., (2012) 36(1): 161-167 doi:10.1016/j.bios.2012.04.006 (IF=5.602);

Diana Machado, Isabel Couto, João Perdigão, Liliana Rodrigues, Isabel Portugal, Pedro Baptista, Bruno Veigas, Leonard Amaral and Miguel Viveiros. Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis. PLoS ONE, (2012) 7(4) e34538 doi:10.1371/journal.pone.0034538 (IF=4.411);

Gonçalo Doria, João Conde, Bruno Veigas, Leticia Giestas, Carina Almeida, Maria Assunção, João Rosa and Pedro V. Baptista*. Noble Metal Nanoparticles for Biosensing Applications. Sensors (Basel), (2012) 12(2): 1657-87 (IF=1.771);

Pedro V. Baptista*. RNA quantification with gold nanoprobes for cancer diagnostics. Clinics in Laboratory Medicine, (2012) 32: 1-13 doi:10.1016/j.cll.2011.09.001 (IF=1.971);

Bassem S. S. Guirgis, Cláudia Sá e Cunha, Inês Gomes, Miguel Cavadas, Isabel Silva, Gonçalo Doria, Gregory L. Blatch, Pedro V. Baptista, Eulália Pereira, Hassan M. E. Azzazy, Maria M. Mota, Miguel Prudêncio, Ricardo Franco. Gold nanoparticle-based fluorescence immunoassay for Malaria antigen detection. Anal.        Bioanal. Chem., (2012) 402:1019–1027 doi:10.1007/s00216-011-5489-y (IF=3.841);

Miguel Larguinho and Pedro V. Baptista*. Gold and silver nanoparticles for clinical diagnostics - from genomics to proteomics. J. Proteomics, 75:2811-2823 (2012) doi:10.1016/j.jprot.2011.11.007 (IF=5.074);

Baptista PV, Doria G, Quaresma P, Cavadas M, Neves CS, Gomes I, Eaton P, Pereira E and Franco R. Nanoparticles in molecular diagnostics. Prog. Mol. Biol. Transl. Sci., (2011) 104:427-88. doi:10.1016/B978-0-12-416020-0.00011-5;

João Conde, Gonçalo Doria and Pedro Baptista*. Noble Metal Nanoparticles Applications in Cancer. J. Drug. Deliv. (2012):751075. Epub 2011. doi:10.1155/2012/751075;

João Conde, João Rosa, João C. Lima, and Pedro V. Baptista*. Nanophotonics for Molecular Diagnostics and Therapy Applications. Int. J. Photoenergy, (2012): 619530, 2012. doi:10.1155/2012/619530 (IF=1.345);

J. P. Rosa, J. C. Lima, P. V. Baptista*. Experimental photophysical characterization of fluorophores on the vicinity of gold nanoparticles - deciphering disputes related to kr determination. Nanotechnology, 22 415202 (2011) doi:10.1088/0957-4484/22/41/415202 (IF=3.979);

Rita Branquinho, Bruno Veigas, J. V. Pinto, R. Martins, Elvira Fortunato, Pedro V. Baptista*. Real-time monitoring of PCR amplification of proto-oncogene c-MYC using a Ta2O5 electrolyte-insulator-semiconductor sensor. Biosens Bioelectron., (2011) 28(1): 44-9 doi:10.1016/j.bios.2011.06.039 (IF=5.602);

Letícia Giestas, João Carlos Lima, Pedro V. Baptista*. Coupling single base extension to a spectral codification tool for increased throughput screening. J. Biotechnol., (2011) 154: 199-204 doi:10.1016/j.jbiotec.2011.05.012 (IF=3.045);

J. Conde, J.M. de la Fuente, P. V. Baptista*. In vitro transcription and translation inhibition via DNA functionalized gold-nanoparticles. Nanotechnology, 21 505101 (2010) doi:10.1088/0957-4484/21/50/505101 (IF=3.979);

André Pinheiro, A. Jorge Parola, Pedro Baptista, João Carlos Lima. pH effect on the photochemistry of 4-methylcoumarin phosphate esters: Caged-Phosphate Case Study. J. Phys. Chem. A, (2010) 114(49): 12795-803 doi:10.1021/jp103045u (IF=2.732);

Leonardo B. Silva, Bruno Veigas, Gonçalo Doria, Pedro Costa, João Inácio, Rodrigo Martins, Elvira Fortunato, Pedro V. Baptista*. Portable optoelectronic biosensing platform for identification of mycobacteria from the Mycobacterium tuberculosis complex. Biosens Bioelectron., (2010) 26(5):2012-7 doi:10.1016/j.bios.2010.08.078 (IF=5.602);

Bruno Veigas, Diana Machado, João Perdigão, Isabel Portugal, Isabel Couto, Miguel Viveiros, Pedro V. Baptista*. Au-nanoprobes for detection of SNPs associated with antibiotic resistance in Mycobacterium tuberculosis. Nanotechnology (2010) 21: 415101 doi:10.1088/0957-4484/21/41/415101 (IF=3.979);

World Gold Council – Highlights from recent literature 2010, Gold Bulletin Vol 43, No 4, 2010

Cristina S. Neves, Pedro Quaresma, Pedro V. Baptista, Patrícia A. Carvalho, João Pedro Araújo, Eulália Pereira, Peter Eaton. New insights into the use of magnetic force microscopy to discriminate between magnetic and nonmagnetic nanoparticles. Nanotechnology, (2010) 21:305706 doi:10.1088/0957-4484/21/30/305706 (IF=3.979);

J. Nanotechnology Highlights 2010

A. Vidal Pinheiro, J. Conde, A. J. Parola, J. C. Lima, P. V. Baptista*. Use of Cyclodextrins as scavengers of inhibitory photo-products in light controlled in vitro synthesis of RNA. J. Photochem. Photobiol. A., (2010) 213:147-151 doi:10.1016/j.jphotochem.2010.05.014 (IF=2.116);

G. Doria, M. Larguinho, J.T. Dias, E. Pereira, R. Franco, P. V. Baptista*. Gold-silver-alloy nanoprobes for one-pot multiplex DNA detection. Nanotechnology (2010) 21:255101 doi:10.1088/0957-4484/21/25/255101 (IF=3.979)

Miguel Larguinho, Hugo M. Santos, Gonçalo Doria, H. Scholz, Pedro V. Baptista, José L. Capelo. Development of a fast and efficient ultrasonic-based strategy for DNA fragmentation. Talanta, (2010) 81(3):881-6 doi:10.1016/j.talanta.2010.01.032 (IF=3.794);

João Conde, Jesús M. de la Fuente, Pedro V. Baptista*. RNA quantification using gold nanoprobes - application to cancer diagnostics. J. Nanobiotechnology., (2010) 8(1):5 doi:10.1186/1477-3155-8-5 (IF=4.08);

Gonçalo Doria, Bernhard G. Baumgartner, Ricardo Franco, Pedro V. Baptista*. Optimizing Au-nanoprobes for specific sequence discrimination. Colloids Surf. B: Biointerfaces, (2010) 77: 122–124 doi:10.1016/j.colsurfb.2010.01.007 (IF=2.780);

Pedro Costa, Ana Amaro, Ana Botelho, João Inácio, Pedro V. Baptista*. Gold nanoprobes assay for identification of mycobacteria from the Mycobacterium tuberculosis complex. Clin Microbiol Infect., (2010) 16: 1464–1469 doi:10.1111/j.1469-0691.2009.03120.x (IF=4.784);

Iwona Bernacka-Wojcik, Rohan Senadeera, Pawel Jerzy Wojcik, Leonardo Bione Silva, Gonçalo Doria, Pedro Baptista, Hugo Aguas, Elvira Fortunato, Rodrigo Martins. Inkjet printed and "doctor blade" TiO2 photodetectors for DNA biosensors. Biosens Bioelectron., (2010) 25(5): 1229-1234 doi:10.1016/j.bios.2009.09.027 (IF=5.602);

Letícia Giestas, Vesselin Petrov, Pedro V. Baptista, João Carlos Lima. General FRET-based coding for application in multiplexing methods. Photochem. Photobiol. Sci., (2009) 8:1130-8 doi:10.1039/b906033b (IF=2.413);

Pedro Viana Baptista*. Cancer Nanotechnology: Prospects for Cancer Diagnostics and Therapy. Curr. Cancer Ther. Rev., (2009) 5:80-88 doi:10.2174/157339409788166733;

André Vidal Pinheiro, Pedro Baptista*, João Carlos Lima. Light activation of transcription: photocaging of nucleotides for control over RNA polymerization. Nucleic Acids Res., (2008) 36(14):e90  doi:10.1093/nar/gkn415 (IF=8.026);

Letícia Giestas, Guilherme N.M. Ferreira, Pedro V. Baptista, João Carlos Lima. Multiplexed spectral coding for simultaneous detection of DNA hybridization reactions based on FRET. Sens. Actuator B-Chem., (2008) 134(1):146-157 doi:10.1016/j.snb.2008.04.038 (IF=3.898);

Rodrigo Martins, Pedro Baptista, Leonardo Silva, Leandro Raniero, Gonçalo Doria, Ricardo Franco, Elvira Fortunato. Identification of unamplified genomic DNA sequences using a novel thin film photodetector. J. Non-Cryst. Solids, (2008) 354(19-25):2580-4 doi:10.1016/j.jnoncrysol.2007.09.074 (IF=1.483);

Leonardo B. Silva, Pedro Baptista, Leandro Raniero, Gonçalo Doria, Rodrigo Martins, Elvira Fortunato. Characterization of optoelectronic platform using an amorphous/nanocrystalline silicon     biosensor for the specific identification of nucleic acid sequences based on gold nanoparticle probes. Sens. Actuator B-Chem., (2008) 132(2): 508-511 doi:10.1016/j.snb.2007.11.015 (IF=3.898);

Pedro Baptista, Eulália Pereira, Peter Eaton, Gonçalo Doria, Adelaide Miranda, Inês Gomes, Pedro Quaresma, Ricardo Franco. Gold Nanoparticles for the Development of Clinical Diagnosis Methods. Anal Bioanal Chem., (2008) 391(3): 943-50 doi:10.1007/s00216-007-1768-z (IF=3.841);

Peter Eaton, Gonçalo Doria, Eulália Pereira, Pedro Baptista, Ricardo Franco. Imaging gold nanoparticles for DNA sequence recognition in biomedical application. IEEE Trans. Nanobiosci., (2007) 6(4): 282-288 doi:10.1109/TNB.2007.912800 (IF=1.712);

Gonçalo Doria, Ricardo Franco, Pedro Baptista*. Nanodiagnostics: Fast Colorimetric Method for Single Nucleotide Polymorphism/Mutation Detection. IET Nanobiotechnol., (2007) 1(4): 53-57 doi:10.1049/iet-nbt:20070001 (IF=1.857);

Jorge Francisco Gaspar, Pedro Viana Baptista, José Rueff. Gold nanoparticle based systems in genetics. Current Pharmacogenomics (2007) 5(1): 39-47 doi:10.2174/157016007780077185 [now Curr. Pharmacogenomics Person. Med.];

Rodrigo Martins, Pedro Baptista, Leandro Raniero, Gonçalo Doria, Leonardo Silva, Ricardo Franco, Elvira Fortunato. Amorphous/nanocrystalline silicon biosensor for the specific identification of unamplified nucleic acid sequences using gold nanoparticle probes. Appl. Phys. Lett., (2007) 90(2): 023903 doi:10.1063/1.2431449 (IF=3.844);

Pedro Viana Baptista*, Maria Koziol-Montewka, Jolanta Paluch-Oles, Gonçalo Doria, Ricardo Franco. Gold Nanoparticle Probe-based Diagnostic System for Rapid and Sensitive Detection of Mycobacterium tuberculosis. Clin. Chem., (2006) 52(7):1433-1434 doi:10.1373/clinchem.2005.065391 (IF=6.886);

Pedro Baptista, Gonçalo Doria, David Henriques, Eulália Pereira, Ricardo Franco. Colorimetric Detection of Eukariotic Gene Expression with DNA-derivatized Gold Nanoparticles. J. Biotechnol., (2005) 119(2):111-117 doi:10.1016/j.jbiotec.2005.02.019 (IF=3.045);

Pedro Viana Baptista*. Principles in Genetic Risk Assessment. Ther. Clin. Risk Manag., (2005) 1: 15-20 (IF=1.469);

Jürgen Groet, Jane H. Ives, Andrew P. South, Pedro R. Baptista, Tania A. Jones, Marie-Laure Yaspo, Hans Lehrach, Marie-Claude Potier, Christine Van Broeckhoven, Dean Nizetic.           Bacterial contig map of the 21q11 region associated with Alzheimer´s disease and abnormal myelopoiesis in Down syndrome. Genome Res., (1998) 8(4): 385-389 doi:10.1101/gr.8.4.385 (IF=13.588);

Rachel H. Flomen, Radost Vatcheva, Patricia AGorman, Pedro R. Baptista, Jürgen Groet, Ingeborg Barisic, Ivo Ligutic, Dean Nizetic. Construction and analysis of a sequence-ready map in 4q25: Rieger syndrome can be caused by haploinsufficiency of RIEG, but also by chromosome breaks ~90Kb upstream of this gene. Genomics, (1998) 47: 409-413 doi:10.1006/geno.1997.5127 (IF=3.327);

 

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