Faculdade

Departamento

Jaime Mota

Professor Auxiliar (c/ Nomeação definitiva)
330B
(+351) 212948300
11118

Interesses Científicos

Our laboratory (sites.fct.unl.pt/infection-biology) aims to understand the molecular and cellular mechanisms by which bacterial pathogens modify the normal functioning of animal host cells. This fundamental knowledge might then be used to develop specific strategies to combat infectious diseases. Because microbial pathogens are the ultimate cell biologists - as they co-evolved with their eukaryotic hosts for millions of years -, we also seek to understand basic eukaryotic cell biology. We focus on the human pathogen Chlamydia trachomatis, which are obligate intracellular bacteria that cause sexually transmitted diseases and ocular infections (trachoma), and on Legionella pneumophila and Salmonella enterica, which are both facultative intracellular bacteria that cause pneumonia (Legionnaire's Disease) and gastrointestinal and systemic diseases (typhoid fever) in humans, respectively.

Publicações Representativas

• Franco, I. S., Pais, S. V, Charro, N., Mota, L. J. (2017) Effector Translocation Assay: Differential Solubilization, Methods Mol Biol. 2017;1615:501-515. doi: 10.1007/978-1-4939-7033-9_35.
 
• da Cunha, M., Pais, S. V., Bugalhão, J. N., Mota, L. J. (2017) The Chlamydia trachomatis type III secretion substrates CT142, CT143, and CT144 are secreted into the lumen of the inclusion. PLoS ONE. 12:e0178856. doi: 10.1371/journal.pone.0178856.
 
Inácio, Â. S, Nunes A., Milho, C., Mota, L. J., Borrego, M. J., Gomes, J. P., Vaz, W. L., Vieira, O. V. (2016) In vitro activity of quaternary ammonium surfactants against streptococcal, chlamydial, and gonococcal infective agents. Antimicrob Agents Chemother. 60:3323-32. doi: 10.1128/AAC.00166-16.

• Domingues, L., Ismail, A., Charro, N., Rodríguez-Escudero, I., Holden, D. W., Molina, M., Cid, V. J., Mota, L. J. (2015). The Salmonella effector SteA binds phosphatidylinositol 4-phosphate for subcellular targeting within host cells. Cell. Microbiol. 18:949-69. doi: 10.1111/cmi.12558

• Bugalhão, J. N., Mota, L. J., Franco, I.S. (2015). Identification of regions within the Legionella pneumophila VipA effector protein involved in actin binding and polymerization and in interference with eukaryotic organelle trafficking. Microbiologyopen. doi: 10.1002/mbo3.316.

• Bugalhão, J. N., Mota, L. J., and Franco, I. S. (2015). Bacterial nucleators: actin' on actin. Pathog Dis. 73. pii: ftv078. doi: 10.1093/femspd/ftv078

• Borges, V., Pinheiro, M., Antelo, M., Sampaio, D. A., Vieira, L., Ferreira, R., Nunes, A., Almeida, F., Mota, L. J., Borrego, M. J., and Gomes, J. P. (2015). Chlamydia trachomatis In Vivo to In Vitro Transition Reveals Mechanisms of Phase Variation and Down-Regulation of Virulence Factors. PLoS One. 10:e0133420. doi: 10.1371/journal.pone.0133420

• Charro, N., Mota, L. J. (2015). Approaches targeting the type III secretion system to prevent or treat bacterial infections. Expert Opin Drug Discov. 10:373-87. doi: 10.1517/17460441.2015.1019860 

• Domingues, L., Holden, D. W., Mota, L. J. The Salmonella effector SteA contributes to the control of membrane dynamics of Salmonella-containing vacuoles (2014).  Infect Immun. 82:2923-34. doi:10.1128/IAI.01385-13 

• da Cunha, M, Milho, C., Almeida, F., Pais, S. V., Borges, V., Maurício, R., Borrego, M. J., Gomes, J. P., Mota, L. J. (2014). Identification of type III secretion substrates of Chlamydia trachomatis using Yersinia enterocolitica as a heterologous system. BMC Microbiol. 14(1):40. doi:10.1186/1471-2180-14-40 

• Pais, S. V., Milho, C., Almeida, F., Mota, L. J. (2013). Identification of novel type III secretion chaperone-substrate complexes of Chlamydia trachomatis. PLoS ONE. 8: e56292. doi: 10.1371/journal.pone.0056292 

• Almeida, F., Borges, V, Ferreira, R., Borrego, M. J., Gomes, J. P, and Mota, L. J. (2012). Polymorphisms in Inc proteins and differential expression of inc genes among Chlamydia trachomatis strains correlate with invasiveness and tropism of lymphogranuloma venereum isolates. J Bacteriol. 194: 6574-6785. doi: 10.1128/JB.01428-12

• McGourty, K. Thurston, T. L., Matthews, S.A., Pinaud, L., Mota, L. J.,  and Holden, D.W. (2012). Salmonella inhibits retrograde trafficking of mannose-6-phosphate receptors and lysosome function. Science. 338:963-967. doi: 10.1126/science.1227037

• Seixas E, Ramalho J, Mota LJ, Barral DC, Seabra MC (2012). Bacteria and protozoa differentialy modulate the expression of Rab proteins. PLoS ONE. 7: e39858. doi: 10.1371/journal.pone.0039858 

• Schroeder, N., Mota, L.J., Méresse, S. (2011). Salmonella-induced tubular networks. Trends Microbiol. 19:268-277. doi: 10.1016/j.tim.2011.01.006

Websites

Lab website