Faculdade

Departamento

Alexandra R. Fernandes

Professor Auxiliar (c/ Nomeação definitiva)
303
11107

Interesses Científicos

Cancer mechanisms and Therapy - novel compounds with anti-cancer activity and their potential use in therapy. Cancer Diagnostics [Co-Founder of FCT/UNL Start up - Nano4 Global, Lda, Nano4Global.com] Cardiology - molecular mechanisms of cardiomyopathies with particular empahsis in Hypertrophic cardiomyopathy (HCM) molecular profiling - [co-Founder of HeartGenetics, SA - Molecular diagnostics Start up - Heartgenetics.com ]

Publicações Representativas

2019

Cinthia Alves-Barroco, Catarina Roma-Rodrigues, Natesan Balasubramanian, Marcia Aparecida Guimarães, Bernadete T. Ferreira-Carvalho, Jayaraman Muthukumaran, Daniela Nunes, Elvira Fortunato, Rodrigo Martins, Teresa Santos-Silva*, Agnes. M.S. Figueiredo*, Alexandra R. Fernandes*, Ilda Santos-Sanches. Biofilm development and computational screening for new putative inhibitors of a homolog of the regulatory protein BrpA in Streptococcus dysgalactiae subsp. dysgalactiae. International Journal of Medical Microbiology 2019 (just accepted) (IF 3.298).

Catarina Roma-Rodrigues, Rita Mendes, Pedro V. Baptista* and Alexandra R. Fernandes*. Targeting tumor microenvironment for cancer therapy. Section Biochemistry: Tumor Microenvironment 2019. International J Molecular Sciences 2019 (Just accepted) (IF 3.687).

Constantina Kourmentza, Diana Araujo, Chantal Servin, Catarina Roma-Rodriques, Joana Lia Ferreira, Madalena Dionisio, Filomena Freitas, Pedro V. Baptista, Alexandra R. Fernandes, Christian Grandfils, Maria A.M. Reis. Occurrence of non-toxic bioemulsifiers during polyhydroxyalkanoate production by Pseudomonas strains valorizing crude glycerol by-product. Bioresource Technology 2019 (accepted) (IF 5.807).

Miguel M. Santos, Luís R. Raposo, Alexandra Costa, Pedro V. Baptista, Alexandra R. Fernandes*, Luís C. Branco*. Ionic Liquids and salts from Ibuprofen: Old drug, new properties. MedChemMed 2019. doi.org/10.1002/cmdc.201900040 (IF 2.3).

Manas Sutradhar, Alexandra R Fernandes,*, Fabiana Paradinha, Patricia Rijo, Catarina Garcia, Catarina Roma-Rodrigues, Armando J. L. Pombeiro, Adília Januário Charmier*. A new Cu(II)-O-Carvacrotinate Complex: synthesis, characterization and biological activity. J Inorganic Biochemistry 2019; 190:31-37. doi:10.1016/j.jinorgbio.2018.09.018 (IF 3.063).

Hélder Oliveira, Catarina Roma-Rodrigues, Ana Santos, Bruno Veigas, Ana Faria, Conceição Calhau, Victor de Freitas, Pedro V. Baptista, Nuno Mateus, Alexandra R. Fernandes, Iva Fernandes. GLUT1 and GLUT3 involvement in anthocyanin gastric transport - Nanobased targeted approach. Scientific Reports 2019. doi: 10.1038/s41598-018-37283-2 (IF 4.122).

2018

Oscar A. Lenis-Rojas, M. Paula Robalob, Ana Isabel Tomaz*, Andreia Carvalho, Alexandra R. Fernandes*, Fernanda Marques, Mónica Folgueira, Julián Yáñez, Digna Vázquez-García, Margarita López Torres, Alberto Fernández, Jesús J. Fernández,*  RuII(p-cymene) compounds as effective and selective anticancer candidates with no toxicity in vivo. Inorg. Chem. 2018; 57:13150–13166. doi: 10.1021/acs.inorgchem.8b01270 (IF 4.7).

Raquel Vinhas, Patrícia Ribeiro, Alexandra Lourenço, Susana Santos, Marcos Lemos, Aida Botelho de Sousa, Pedro V. Baptista, Alexandra R. Fernandes*. A novel BCR-ABL1 mutation in a patient with Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia. Oncotargets and Therapy 2018; 2018:8589—8598. doi:10.2147/OTT.S177019 (IF 2.656).

Noora Svahn, Artur J. Moro, Catarina Roma-Rodrigues, Rakesh Puttreddy, Kari Rissanen, Pedro V. Baptista, Alexandra R. Fernandes*, João Carlos Lima, Laura Rodríguez*. The important role of the nuclearity, rigidity and solubility of phosphane ligands on the biological activity of gold(I) complexes. Chemistry – an European Journal 2018; 24:14654-14667. doi:10.1002/chem.201802547. (selected for cover) (IF 5.16).

Raquel Vinhas, Patrícia Ribeiro, Alexandra Lourenço, Susana Santos, Madalena Silva, Aida Botelho de Sousa, Pedro V. Baptista, Alexandra R. Fernandes*. A double Philadelphia chromosome-positive chronic myeloid leukemia patient, co-expressing P210BCR-ABL1 and P195BCR-ABL1 isoforms. Haematologica 2018; 103:e549-e552. doi:10.3324/haematol.2018.192534 (IF 9.09).

Pedro Pedrosa, Rita Mendes, Rita Cabral, Luisa Martins; Pedro V Baptista* and Alexandra R Fernandes*. Combination of chemotherapy and Au-nanoparticle photothermy in the visible to tackle drug resistance in cancer cells. Scientif Reports 2018; 8:11429. doi:10.1038/s41598-018-29870-0 (IF 4.122).

R. B. Restani, R. F. Pires, A Tomatcheva, Rita Cabral, Pedro V. Baptista, A. R. Fernandes, T. Casimiro, V. D. B. Bonifácio and A. Aguiar-Ricardo. Nano-in-micro engineered dry powder formulations for inhalation chemotherapy. Chemistry Open. 2018; 7:751-751. doi: 10.1002/open.201800093. (selected for cover) (IF 2.801).

Pedro V. Baptista*, Matthew P. McCusker, Andreia Carvalho, Daniela Alves Ferreira, Niamh Máire Mohan, Marta Martins* and Alexandra R. Fernandes*. Nano-Strategies to fight Multidrug Resistant Bacteria – “A battle of the titans”. Front Microbiol. 2018; 9:1441. doi: 10.3389/fmicb.2018.01441. eCollection 2018 (IF 4.076).

Kuheli Das, Belete B. Beyene, Amitabha Datta,*, Eugenio Garribb, Catarina Roma-Rodrigues, Ana Silva, Alexandra R. Fernandes*, Chen-Hsiung Hung*. EPR and Electrochemical Interpretation of Bispyrazolylacetate Anchored Ni(II) and Mn(II) Complexes: Cytotoxicity and Anti-proliferative Activity on Human Cancer Cell Lines. New J Chem. 2018; 42:9126-9139. doi:10.1039/C8NJ01033A (IF 3.201).

Anna Maroń, Katarzyna Czerwińska, Barbara Machura,*, Luis Raposo, Catarina Roma-Rodrigues, Alexandra R Fernandes,* Jan Grzegorz Małecki, Agata Szlapa-Kula, Slawomir Kula, Stanisław Krompiec. Spectroscopy, electrochemistry and antiproliferative properties of Au(III), Pt(II) and Cu(II) complexes bearing modified 2,2':6',2"-terpyridine ligands. Impact of metal center and substituent incorporated into terpy framework. Dalton Trans 2018; 47:6444-6463. doi:10.1039/C8DT00558C (IF 4.099).

Tânia S. Morais, Yann Jousseaume, M. Fátima M. Piedade, Catarina Roma-Rodrigues, Alexandra R. Fernandes, Fernanda Marques, Maria J. Villa de Brito, M. Helena Garcia. Important cytotoxic and cytostatic effects of new copper(I)–phosphane compounds with N,N, N,O and N,S bidentate ligands. Dalton Trans 2018; 47:7819-7829. doi: 10.1039/C8DT01653D (IF 4.099).

Chandramohan Bathula, Catarina Roma-Rodrigues, Alexandra R. Fernandes* and Subhabrata Sen*. Synthesis of tetrahydro-1H-indolo[2,3-b]pyrrolo[3,2-c]quinolones via intramolecular oxidative ring rearrangement of tetrahydro-β-carbolines and their biological evaluation. New J. Chem. 2018; 42:6538-6547. doi: 10.1039/C7NJ04616B (IF 3.201).

Cinthia Alves-Barroco, Catarina Roma-Rodrigues, Luís R. Raposo, Catarina Brás, Mário Diniz, João Caço, Pedro M. Costa, Ilda Santos-Sanches, Alexandra R. Fernandes*. Streptococcus dysgalactiae subsp. dysgalactiae isolated from milk of the bovine udder as emerging pathogens: in vitro and in vivo infection of human cells and zebrafish (Danio rerio) as biological models. MicrobiologyOpen 2018 Mar 25:e00623. doi: 10.1002/mbo3.623 (IF 2.682).

A.P.C. Ribeiro, S. Anbu, E.C.B.A. Alegria, A.R. Fernandes, P.V. Baptista, R. Mendes, A.S. Santos, M. Mendes, M.F.C. Guedes da Silva, A.J.L. Pombeiro. Cell Cytotoxicity, DNA/BSA binding of green-synthesized silver nanoparticles. Biomed Pharmacother 2018; 101:137-144. doi: 10.1016/j.biopha.2018.02.069 (IF 3.452).

Gomes S.E., Pereira D.M., Roma-Rodrigues C., Fernandes A.R.*, Borralho P.M.B., Rodrigues C.M.P.*. Proteomic analysis of HCT116 colon cancer cells overexpressing miR-143 and miR-145. PLoS ONE 2018; 13(1): e0191607. DOI. 10.1371/journal.pone.0191607 (IF 2.766).

Ana Sofia Matias, Raquel Vinhas, Rita Mendes, Alexandra R. Fernandes and Pedro V Baptista. Nanoparticles as emerging diagnostic tools in liquid tumours. European Medical J Innov. 2018;2[1]:80-87.

Peixoto, Daniela; Figueiredo, Margarida; Malta, Gabriela; Roma-Rodrigues, Catarina; Baptista, Pedro; Fernandes, Alexandra R; Barroso, Sónia; Carvalho, Ana Luisa; Afonso, Carlos; Ferreira, Luisa; Branco, Paula. Synthesis, cytotoxicity evaluation in human cell lines and in vitro DNA interaction of a hetero arylidene-9,10-anthrone. European Journal of Organic Chemistry. 2018; 2018(4):545-549. DOI 10.1002/ejoc.201701500 (IF 2.822).

Pedro Urbano Alves, Raquel Vinhas, Alexandra R. Fernandes, Semra Zuhal Birol, Levent Trabzon, Iwona Bernacka-Wojcik, Rui Igreja, Paulo Lopes, Pedro Viana Baptista, Hugo Águas, Elvira Fortunato, Rodrigo Martins. Multifunctional microfluidic chip for gold nanoprobe based RNA detection with built-in passive micromixer and optical detection modules – application to Chronic Myeloid Leukemia. Scientific Reports 2018; 8:381. DOI:10.1038/s41598-017-18725-9 (IF 4.122).

 

2017

Raquel Vinhas, Rita Mendes, Alexandra R. Fernandes, Pedro V. Baptista*. Nanoparticles – Emerging potential for managing leukemia and lymphoma. Bioeng. Biotechnol., Front Bioeng Biotechnol. 2017;5:79. doi: 10.3389/fbioe.2017.00079. eCollection 2017.

Pedro Pedrosa, Amelie Heuer-Jungemann, Antonios G. Kanaras, Alexandra R. Fernandes and Pedro V. Baptista*. Potentiating angiogenesis arrest in vivo via laser irradiation of peptide functionalised gold nanoparticles. J Nanobiotechnology 2017; 15: 85.

Rita Mendes, Pedro Pedrosa, João C. Lima, Alexandra R. Fernandes*, Pedro V. Baptista*. Photothermal enhancement of chemotherapy in breast cancer by visible irradiation of Gold Nanoparticles. Scientific Reports 2017, 7, 10872. doi:10.1038/s41598-017-11491-8.

Joana R. Sousa, Célia M. Silveira, Catarina Roma-Rodrigues, Alexandra R. Fernandes, Bart Devreese, Isabel Moura, José J.G. Moura, M. Gabriela Almeida,*. Understanding the response of Desulfovibrio desulfuricans ATCC 27774 to different electron acceptors - biosynthetic costs modulate substrate selection. BBA - Proteins and Proteomics 2017 Nov;1865(11 Pt A):1455-1469. doi: 10.1016/j.bbapap.2017.07.021.

Luiz Gonzaga do Nascimento-Netoa, Maria Guadalupe Cabral, Rômulo Farias Carneiro, Francisco Vassiliepe Sousa Arruda, Zélia Silva, Celso Shiniti Nagano, Alexandra R Fernandes, Alexandre Holanda Sampaio, Edson Holanda Teixeira and Paula Alexandra Videira. Halilectin-3, a lectin from the marine sponge Haliclona caerulea, induces apoptosis and autophagy in human breast cancer MCF7 cells through a caspase-9 and LC3 pathway. Anti-Cancer Agents in Medicinal Chemistry 2017, Nov 13. doi: 10.2174/1871520617666171114094847.

Katarzyna Czerwinska, Barbara Machura* Slawomir Kula, Stanislaw Krompiec, Catarina Roma-Rodrigues, Alexandra R. Fernandes*, Lidia S. Shul’pina and Georgiy B. Shul’pin*. Copper(II) complexes of functionalized 2,2':6',2''-terpyridines and 2,6-di(thiazol-2-yl)pyridine: structure, spectroscopy, cytotoxicity and catalytic activity. Dalton Trans. 2017 Jul 25;46(29):9591-9604. doi: 10.1039/c7dt01244f..

Manas Sutradhar,* Rajeshwari, Tannistha Roy Barman, Alexandra R Fernandes* Fabiana Paradinha, Catarina Roma-Rodrigues, M. Fátima C. Guedes da Silva, and Armando J. L. Pombeiro*. Mixed ligand aroylhydrazone and N-donor heterocyclic Lewis base Cu(II) complexes as potential antiproliferative agents. J Inorg Biochem 2017 Oct;175:267-275. doi: 10.1016/j.jinorgbio.2017.07.034.

Márcia Tavares, Renato P. Cabral, Clarinda Costa, Pedro Martins, Alexandra R. Fernandes, Teresa Casimiro, Ana Aguiar-Ricardo. Development of PLGA dry powder microparticles by supercritical CO2-assisted spray-drying for potential vaccine delivery to the lungs. The Journal of Supercritical Fluids 2017; 128: 235-243.

Oscar A. Lenis-Rojas, Catarina Roma-Rodrigues, Alexandra R. Fernandes*, Fernanda Marques, David Pérez-Fernández, Jorge Guerra-Varela, Laura Sánchez, Digna Vázquez-García, Margarita López Torres, Alberto Fernández, Jesús J. Fernández*. Dinuclear RuII(bipy)2 Derivatives: Structural, Biological and In Vivo Zebrafish Toxicity Evaluation. Inorganic Chemistry 2017. 56 (12), pp 7127–7144.

Alexandra R. Fernandes*, João Jesus, Pedro Martins, Sara Figueiredo, Daniela Rosa, Luísa M.R.D.R.S. Martins, Maria Luísa Corvo, Manuela C. Carvalheiro, Pedro M. Costa, Pedro V. Baptista*. Multifunctional gold-nanoparticles: a nanovectorization tool for the targeted delivery of novel chemotherapeutic agents. Journal of Control Release 2017, 245:52-61. doi.org/10.1016/j.jconrel.2016.11.021.

Raquel Vinhas, Alexandra R. Fernandes*, Pedro V. Baptista*. Gold nanoparticles for BCR-ABL1 gene silencing – Improving tyrosine kinase inhibitors efficacy in chronic myeloid leukemia. Mol Ther Nucleic Acids. 2017, 7:408-416. doi.org/10.1016/j.omtn.2017.05.003.

Rita Mendes, Alexandra R. Fernandes* and Pedro V. Baptista*. Gold nanoparticle approach to the selective delivery of gene silencing in cancer – the case for combined delivery? Clinical Genomics in Genetic Diseases and Cancer. Genes 2017, 8:94.

Catarina Roma-Rodrigues, Francisca Pereira, António P. Alves de Matos, Marta Fernandes, Pedro V. Baptista,* AND Alexandra R. Fernandes,* Smuggling gold nanoparticles across cell types – a new role for exosomes in gene silencing. Nanomedicine. 2017 Jan 28;13(4):1389-1398.

Catarina Roma-Rodrigues, Luís R. Raposo, Rita Cabral, Fabiana Paradinha, Pedro V Baptista* AND Alexandra R Fernandes*. Tumor microenvironment modulation via gold nanoparticles targeting malicious exosomes: implications in cancer diagnostics and therapy. Int J Mol Sci. 2017 Jan 14;18(1).

Luís R. Raposo, Catarina Roma-Rodrigues, João Jesus, Luísa M.D.R.S. Martins, Armando J Pombeiro, Pedro V. Baptista*, Alexandra R. Fernandes*. Targeting canine mammary tumors via gold nanoparticles functionalized with promising Co(II) and Zn(II) compounds. Veterinary and Comparative Oncology 2017; 1–6.

Milton Cordeiro, Lara Carvalho, Joana Filipa Silva, Leonor Saúde, Alexandra R Fernandes, Pedro V. Baptista *. Gold nanobeacons for tracking gene silencing in zebrafish. Nanomaterials (Basel). 2017 Jan 11;7(1).

 

2016

Susana I. C. J. Palma, Alexandra R. Fernandes and Ana C. A. Roque. An affinity triggered MRI nanoprobe for pH-dependent cell labeling. RSC Adv., 2016,6, 113503-113512.

Raquel Vinhas, Milton Cordeiro, Pedro Pedrosa, Alexandra R. Fernandes*, Pedro V. Baptista*. Current trends in molecular diagnostics of Chronic Myeloid Leukemia. Leuk Lymphoma. 2017,58:1791-1804

O. A. Lenis-Rojas, A.R. Fernandes*, C. Rodrigues, P. V. Baptista, F. M. Marques, D. Pérez-Fernández, J. Guerra, L. E. Sanchez, D. Vazquez-Garcia, M. Lopez-Torres, A. Fernández and J. J. Fernández Sánchez*. Heteroleptic mononuclear compounds of ruthenium(II): synthesis, structural analyses, in vitro antitumor activity and in vivo toxicity on zebrafish embryos. Dalton Trans., 2016,45:19127-19140.

Mariana Silva, Zélia Silva, Graça Marques, Tiago Ferro, Márcia Gonçalves, Mauro Monteiro, Sandra J. van Vliet, Elodie Mohr, Andreia C. Lino, Alexandra R. Fernandes, Flávia A. Lima, Yvette van Kooyk, Teresa Matos, Carlos E. Tadokoro and Paula A. Videira. Sialic acid removal from dendritic cells improves antigen cross-presentation and boosts anti-tumor immune responses. Oncotarget 2016, 7:41053-41066.

Raquel Vinhas, Cláudia Correia, Patricia Ribeiro, Alexandra Lourenço, Aida Botelho de Sousa, Alexandra R. Fernandes AND Pedro V. Baptista*. Colorimetric assessment of BCR-ABL1 transcripts in clinical samples via gold nanoprobes. Anal Bioanal Chem 2016, 408:5277–5284.

C. Roma-Rodrigues, A. Heuer-Jungemann, A. R. Fernandes, A. G. Kanaras and P. V. Baptista. Peptide coated gold nanoparticles for in vivo targeting of angiogenesis. Int J Nanomedicine. 2016; 11: 2633–2639.

Rita Mendes, Bárbara Carreira, Pedro V. Baptista* and Alexandra R. Fernandes*. Non-small lung cancer biomarkers and targeted therapy - two faces of the same coin fostered by Nanotechnology. Expert Review of Precision Medicine and Drug Development. 2016; 1(2): 155-168.

Luisa Corvo, Ana Soraia Mendo, Sara Figueiredo, Miguel Larguinho, Rogério Gaspar, Pedro V. Baptista* and Alexandra R. Fernandes*. Liposomes as delivery system of a Sn(IV) compound for cancer therapy. Pharm Res. 2016 Jun;33(6):1351-8. doi: 10.1007/s11095-016-1876-6.

Luís R. Raposo, Catarina Roma-Rodrigues, Pedro Faísca, Margarida Alves, Joaquim Henriques, Manuela C. Carvalheiro, M. Luisa Corvo, Pedro V. Baptista, Armando JL Pombeiro, Alexandra R. Fernandes*. Immortalization and characterization of a new canine mammary tumor cell line FR37-CMT. J. Veterinary and Comparative Oncology 2016. DOI: 10.1111/vco.12235.

Marta Martins, Pedro V. Baptista, Ana Soraia Mendo, Claudia Correia, Paula Videira, António S. Rodrigues, J. Muthukumaran, Teresa Santos-Silva, Ana Silva, M. Fátima C. Guedes da Silva, Joana Gigante, António Duarte, Armando J. L. Pombeiro, Alexandra R. Fernandes*. In vitro and in vivo biological characterization of the anti-proliferative potential of a cyclic trinuclear organotin(IV) complex.  Mol Biosyst. 2016 Mar;12(3):1015-23. doi: 10.1039/c5mb00791g.

Zhen Ma*, Bian Zhang, M. Fátima C. Guedes da Silva, Ana Soraia Mendo, Joana Silva, Pedro V. Baptista, Alexandra R. Fernandes*, Armando J.L. Pombeiro*. Synthesis, Characterization, Thermal Properties and Antiproliferative Potential of Copper(II) 4′-phenyl-terpyridine Compounds. Dalton Trans. 2016 Mar 28;45(12):5339-55. doi: 10.1039/c5dt02744f.

Sutradhar, M, Fernandes AR*, Silva J, Mahmudov KT, da Silva FGMC, Pombeiro AJL.  Water soluble heterometallic potassium-dioxidovanadium(V) (K+/VO3+) complexes as potential antiproliferative agents. J Inorg Biochem. 2016; 155:17-25.

Catarina Roma-Rodrigues, Cynthia Barroco, Luís R Raposo, Mafalda N Costa, Elvira Fortunato, Pedro Viana Baptista, Alexandra R Fernandes*, Ilda Santos-Sanches*. Infection of human keratinocytes by Streptococcus dysgalactiae subspecies dysgalactiae isolated from milk of the bovine udder. Microbes Infect. 2016 Apr;18(4):290-3. doi: 10.1016/j.micinf.2015.11.005.

Raquel Vinhas, Anna Tolmatcheva, Rafaela Canto, Patricia Ribeiro, Alexandra Lourenço, Aida Botelho de Sousa, Pedro V. Baptista, Alexandra R. Fernandes*. A novel mutation in the CEBPA gene in a patient with acute myeloid leukemia. Leuk Lymphoma. 2016;57(3):711-3. doi: 10.3109/10428194.2015.