Isabel Sá Nogueira

Professora Associada com Agregação

(+351) 21 294 85 30 11104

Áreas de Investigação

The research in our laboratory focuses on the mechanisms that control gene expression. The main area of interest is to understand how the transcriptional and translational regulatory networks interact with other cellular components such as the metabolic system. This involves the analysis of the mechanisms
through which the cell senses nutrient availability and transmits that information to the level of gene expression. It also involves looking at the transcription and translation control, which govern the expression of genes involved in carbohydrate metabolism.

Lab's website -

Publicações Representativas

Godinho, L.M., and I. de Sá-Nogueira. (2011). Characterization and regulation of a bacterial sugar phosphatase of the HAD superfamily AraL from Bacillus subtilis. FEBS Journal 278: 2511-2524. doi: 10.1111/j.1742- 4658.2011.08177.x

Ferreira, M.J., and I. de Sá-Nogueira. (2010). A multitask ATPase serving different ABC-type sugar importers in Bacillus subtilis. Journal of Bacteriology 192 (20): 5312-5318. doi: 10.1128/JB.00832-10

Inácio, J.M., and I. de Sá-Nogueira. (2008). Characterization of the abn2(yxiA) encoding a Bacillus subtilis GH43 arabinanase, Abn2, and its role in arabino- polysaccharides degradation. Journal of Bacteriology 190: 4272-4280. doi:10.1128/JB.00162-08

Franco, I.S., L.J. Mota, C.M. Soares, and I. de Sá-Nogueira. (2007). Probing key DNA contacts in AraR-mediated transcriptional repression of the Bacillus subtilis arabinose regulon. Nucleic Acids Research 35: 4755–4766. Open Access. doi:10.1093/nar/gkm509

Mota, L.J., P. Tavares, and I. de Sá-Nogueira. (1999). Mode of action of AraR, the key regulator of L-arabinose metabolism in Bacillus subtilis. Molecular Microbiology 33: 476-489. DOI: 10.1046/j.1365- 2958.1999.01484.x