Paula Gonçalves

Professor Auxiliar (c/ Nomeação definitiva)

Gabinete 303, Ed. Departamental
Labs. 319 e 305

(+351) 21 294 85 30 11107
pmz@fct.unl.pt

Áreas de Investigação

My main current research interest is to make use of the empowerment provided by functional genomics to develop original, multidisciplinary approaches to link yeast evolution to phenotypic divergence, speciation and ecology. The focus is presently on Saccharomyces species.
In addition, I am also keenly interested in the evolution of sexual system s I basidiomycetes, in particular within the red yeasts of the Sporidiobolales.

Publicações Representativas


Barbosa R, Almeida P, Safar SV, Santos RO, Morais PB, Nielly-Thibault L, Leducq JB, Landry CR, Gonçalves P, Rosa CA, Sampaio JP. Evidence of natural hybridization in Brazilian wild lineages of Saccharomyces cerevisiae. Genome Biol Evol. 2016 (in press).


 Hittinger CT, Rokas A, Bai FY, Boekhout T, Gonçalves P, Jeffries TW, Kominek J, Lachance MA, Libkind D, Rosa CA, Sampaio JP, Kurtzman CP. Genomics and the making of yeast biodiversity. Curr Opin Genet Dev. 2015;35:100-9. doi:10.1016/j.gde.2015.10.008.


Gonçalves C, Coelho MA, Salema-Oom M, Gonçalves P. Stepwise Functional Evolution in a Fungal Sugar Transporter Family. Mol Biol Evol. 2016;33:352-66. doi: 10.1093/molbev/msv220.


 Almeida P, Barbosa R, Zalar P, Imanishi Y, Shimizu K, Turchetti B, Legras JL, Serra M, Dequin S, Couloux A, Guy J, Bensasson D, Gonçalves P, Sampaio JP. A population genomics insight into the Mediterranean origins of wine yeast domestication. Mol Ecol. 2015 ;24:5412-27. doi: 10.1111/mec.13341.


 Maia TM, Lopes ST, Almeida JM, Rosa LH, Sampaio JP, Gonçalves P, Coelho MA. Evolution of Mating Systems in Basidiomycetes and the Genetic Architecture Underlying Mating-Type Determination in the Yeast Leucosporidium scottii. Genetics. 2015 ;201:75-89. doi: 10.1534/genetics.115.177717.


 Coelho MA, Almeida JM, Hittinger CT, Gonçalves P. Draft Genome Sequence of Sporidiobolus salmonicolor CBS 6832, a Red-Pigmented Basidiomycetous Yeast. Genome Announc. 2015 May 21;3(3). pii: e00444-15. doi: 10.1128/genomeA.00444-15.


 de García V, Coelho MA, Maia TM, Rosa LH, Vaz AM, Rosa CA, Sampaio JP, Gonçalves P, van Broock M, Libkind D. Sex in the cold: taxonomic reorganization of psychrotolerant yeasts in the order Leucosporidiales. FEMS Yeast Res. 2015;15:fov019. doi: 10.1093/femsyr/fov019. 


Almeida P, Gonçalves C, Teixeira S, Libkind D, Bontrager M, Masneuf-Pomarède I, Albertin W, Durrens P, Sherman DJ, Marullo P, Hittinger CT, Gonçalves P, Sampaio JP. A Gondwanan imprint on global diversity and domestication of wine and cider yeast Saccharomyces uvarum. Nat Commun. 2014 2;5:4044. doi:10.1038/ncomms5044.


Peris D, Sylvester K, Libkind D, Gonçalves P, Sampaio JP, Alexander WG, Hittinger CT. Population structure and reticulate evolution of Saccharomyces eubayanus and its lager-brewing hybrids. Mol Ecol. 2014 Apr;23(8):2031-45. doi: 10.1111/mec.12702.


 Coelho MA, Gonçalves C, Sampaio JP, Gonçalves P. Extensive intra-kingdomhorizontal gene transfer converging on a fungal fructose transporter gene. PLoS Genet. 2013 Jun;9(6):e1003587. doi: 10.1371/journal.pgen.1003587.


Coelho MA, Sampaio JP, Gonçalves P. Living and thriving on the skin:Malassezia genomes tell the story. MBio. 2013 19;4:e00117-13. doi:10.1128/mBio.00117-13.


 Gomes-Rezende JA, Gomes-Alves AG, Menino JF, Coelho MA, Ludovico P, Paula Gonçalves, Mark H. J. Sturme, Fernando Rodrigues. (2012) Functionality of the Paracoccidioides Mating a-Pheromone-Receptor System. PLoS ONE 7(10): e47033


Anjos J, de Sousa HR, Roca C, Cássio F, Luttik M, Pronk JT, Salema-Oom M, Gonçalves P. (2012) Fsy1, the sole hexose-proton transporter characterized inSaccharomyces yeasts, exhibits a variable fructose:H(+) stoichiometry. Biochim Biophys Acta (in press).


Libkind D, Hittinger CT, Valério E, Gonçalves C, Dover J, Johnston M, Gonçalves P, Sampaio JP. Microbe domestication and the identification of the wild genetic stock of lager-brewing yeast. Proc Natl Acad Sci U S A. (2011) 30;108:14539-44. 


Coelho MA, Gonçalves P, Sampaio JP. (2011) Evidence for maintenance of sex determinants but not of sexual stages in red yeasts, a group of early diverged basidiomycetes. BMC Evol Biol. 31;11:249. 


Coelho MA, Sampaio JP, Gonçalves P. (2010) A deviation from the bipolar-tetrapolar mating paradigm in an early diverged basidiomycete.PLoS Genet. 6 (8).


Remarkably ancient balanced polymorphisms in a multi-locus gene network (2010) Hittinger C.T. Gonçalves P., Sampaio, J P , Dover, J , Johnston, M., Rokas, A. Nature [link]


Leandro MJ, Fonseca C, Gonçalves P. (2009) Hexose and pentose transport in ascomycetous yeasts: an overview. FEMS Yeast Res. 9, 511-525. [link]


Leandro M.J., Spencer-Martins I., Gonçalves P. (2008). The expression in Saccharomyces cerevisiae of a glucose/xylose symporter from Candida intermedia is affected by the presence of a glucose/xylose facilitator. Microbiology, 154:1646-1655 [link]


Coelho M.A., Rosa A., Rodrigues N., Fonseca A., Gonçalves P. (2008). Identification of mating type genes in the bipolar basidiomycetous yeast Rhodosporidium toruloides: first insight into the MAT locus structure of the Sporidiobolales. Eukaryot Cell., 71053-71061. [link]


Sampaio J.P., Gonçalves P.(2008). Natural populations of Saccharomyces kudriavzevii in Portugal are associated with oak bark and are sympatric with S. cerevisiae and S. paradoxus. Appl Environ Microbiol., 74:2144-52. [link]