Isabel Sá Nogueira

Professora Catedrática
(+351) 21 294 85 30

Interesses Científicos

Main field of research is Molecular Microbiology and Microbial Genetics, in particular the control gene expression of carbohydrate metabolism and transport in bacteria. The main area of interest in our lab (sites.fct.unl.pt/microbial-genetics/) is to understand how the transcriptional and translational regulatory networks interact with other cellular components such as the metabolic system. This involves the analysis of the mechanisms through which the cell senses nutrient availability and transmits that information to the level of gene expression. It also involves looking at the transcription and translation control, which govern the expression of genes involved in carbohydrate metabolism in the Gram-positive model organism Bacillus subtilis. Current subjects of interest are: the use of B. subtilis as model for the study of multitask ATPases from ABC-type I sugar importers in pathogenic bacteria; characterization hemicellulases from Bacillus sp; the study of the antimicrobial activity of natural and new compounds/materials. Lab's website - http://sites.fct.unl.pt/microbial-genetics/

Publicações Representativas

Ferreira, MJ, Mendes AL, and de Sá Nogueira I (2017) The MsmX ATPase plays a crucial role in pectin mobilization by Bacillus subtilis. PLoS One. 2017 Dec 14;12(12):e0189483. doi: 10.1371/journal.pone.0189483.


Pedras B., Salema-Oom M., Sá-Nogueira I., Simões P., Paiva A., Barreiros S. (2017). Valorization of white wine grape pomace through application of subcritical water: Analysis of extraction, hydrolysis, and biological activity of the extracts obtained. Journal of Supercritical Fluids, 128, p138-144.  doi:  10.1016/j.supflu.2017.05.020


Aroso IM, Silva JC, Mano F, Ferreira AS, Dionísio M, Sá-Nogueira I, Barreiros S, Reis RL, Paiva A, Duarte AR. (2016) Dissolution enhancement of active pharmaceutical ingredients by therapeutic deep eutectic systems. Eur J Pharm Biopharm. 98:57-66. doi: 10.1016/j.ejpb.2015.11.002.


Correia IL, Franco IS, de Sá-Nogueira I. (2014) Towards novel amino acid-base contacts in gene regulatory proteins: AraR-a case study. PLoS One. 2014 Nov 3;9(11):e111802. doi: 10.1371/journal.pone.0111802.

de Sanctis, D., Inácio, J., Lindley, P., de-Sá-Nogueira I. and Bento, I.(2010) New evidence for the role of calcium in the glycosidase reaction of GH43 arabinanases. FEBS Journal 277(21): 4562-4574.  doi: 10.1111/j.1742-4658.2010.07870.x

dinho, L.M., and I. de Sá-Nogueira. (2011). Characterization and regulation of a bacterial sugar phosphatase of the HAD superfamily AraL from Bacillus subtilis. FEBS Journal 278: 2511-2524. doi: 10.1111/j.1742- 4658.2011.08177.x

Ferreira, M.J., and I. de Sá-Nogueira. (2010). A multitask ATPase serving different ABC-type sugar importers in Bacillus subtilis. Journal of Bacteriology 192 (20): 5312-5318. doi: 10.1128/JB.00832-10

Inácio, J.M., and I. de Sá-Nogueira. (2008). Characterization of the abn2(yxiA) encoding a Bacillus subtilis GH43 arabinanase, Abn2, and its role in arabino- polysaccharides degradation. Journal of Bacteriology 190: 4272-4280. doi:10.1128/JB.00162-08

Franco, I.S., L.J. Mota, C.M. Soares, and I. de Sá-Nogueira. (2007). Probing key DNA contacts in AraR-mediated transcriptional repression of the Bacillus subtilis arabinose regulon. Nucleic Acids Research 35: 4755–4766. Open Access. doi:10.1093/nar/gkm509

Mota, L.J., P. Tavares, and I. de Sá-Nogueira. (1999). Mode of action of AraR, the key regulator of L-arabinose metabolism in Bacillus subtilis. Molecular Microbiology 33: 476-489. DOI: 10.1046/j.1365- 2958.1999.01484.x


Lab's Website -