Alexandra R. Fernandes

Professora Auxiliar (c/ Nomeação definitiva)

Interesses Científicos

Cancer mechanisms and Therapy - novel compounds with anti-cancer activity and their potential use in therapy. Cancer Diagnostics [Co-Founder of FCT-NOVA Start up - Nano4 Global, Lda, Nano4Global.com] Cardiology - molecular mechanisms of cardiomyopathies with particular empahsis in Hypertrophic cardiomyopathy (HCM) molecular profiling - [co-Founder of HeartGenetics, SA - Molecular diagnostics Start up - Heartgenetics.com ]

Publicações Representativas


Nazanin Kordestani, Hadi Amiri Rudbari,*,Alexandra R. Fernandes,*, Luís R. Raposo, André Luz, Pedro V. Baptista, Giuseppe Bruno, Rosario Scopelliti, Zohreh Fateminia, Nicola Micale, Nikolay Tumanov, Johan Wouters,  Abolghasem Abbasi Kajani, Abdol-Khalegh Bordbar. Copper(II) complexes with tridentate halogen‐substituted Schiff base ligands: synthesis, crystal structures and investigating the effect of halogenation, leaving group and ligand flexibility on antiproliferative activities. Dalton Trans 2021 accepted.

Francisco Reigosa-Chamorro, Luís R Raposo, Paula Munín-Cruz, M. Teresa Pereira, Catarina Roma-Rodrigues, Pedro V Baptista,Alexandra R Fernandes* José M. Vila*. In vitro and in vivo effect of PALLADACYCLES: targeting A2780 ovarian carcinoma cells and modulation of angiogenesis. Inorganic Chemistry 2021 accepted.

Lorenzo Rivas-García, José L. Quiles, Catarina Roma-Rodrigues, Luis R. Raposo, María D. Navarro-Hortal, Jose M. Romero-Márquez, Adelaida Esteban-Muñoz, Alfonso Varela-López, Laura Carrera García, Danila Ciancios, Francesca Giampieric, Maurizio Battino, Juan Llopis,Alexandra R. Fernandes*, Pedro V. Baptista, Cristina Sánchez-González*. Rosa x hybrida extracts with dual actions: antiproliferative effects against tumor cells and inhibitor of Alzheimer disease. Food and Chemical Toxicology 2021, 149: 112018. https://doi.org/10.1016/j.fct.2021.112018. (IF-4.679). 

Ferreira-Silva, M., Faria-Silva, C., Baptista, P.V., Fernandes, E., Fernandes, A.R*., Corvo, M.L.*, Drug delivery nanosystems targeted to hepatic ischemia and reperfusion injury.  Drug Delivery and Translational Research 2021. Accepted (IF 2.664).

Ana P. Rodrigo*, Ana R. Grosso, P.V Baptista,Alexandra R. Fernandes*, Pedro M. Costa*. A phylogenetic approach to the recruitment of venom proteins in a marine Polychaeta. Toxins 2021. DOI.10.3390/toxins13020097 (IF 3,531). (Selected for COVER)

A.P. Rodrigo*, V.M. Mendes, B. Manadas, A.R. Grosso, A.P. Alves de Matos, P. V. Baptista, P.M. Costa*,A.R. Fernandes* Specific antiproliferative properties of proteinaceous toxin secretions from a marine annelid Eulalia sp. onto ovarian cancer cells. Marine drugs 2021, 19, 31. https://doi.org/10.3390/md19010031 (IF 4,073).

Catarina Roma-Rodrigues, Luís R. Raposo, Rúben Valente,Alexandra R. Fernandes, Pedro V. Baptista*. Combined cancer therapeutics - tackling the complexity of the tumor microenvironment. WIREs Nanomedicine & Nanobiotechnology 2021 (accepted) (IF 7,689).

Diogo A. Sequeira, Pedro V. Baptista, Ruben Valente, M. Fátima M. Piedade, M. Helena Garcia, Tânia S. Morais* and Alexandra R. Fernandes*. Cu(I) complexes as new antiproliferative agents against sensitive and doxorubicin resistant colorectal cancer cells: Synthesis, Characterization, and Mechanisms of Action. Dalton Trans., 2021, 50:1845. DOI: 10.1039/D0DT03566A (IF 4,052).

Luís R. Raposo, Ana Silva, Dário Silva, Catarina Roma-Rodrigues, Margarida Espadinha, Pedro V. Baptista, Maria M. M. Santos* and Alexandra R Fernandes*. Exploiting the antiproliferative potential of spiropyrazoline oxindoles in a human ovarian cancer cell line. Bioorganic & Medicinal Chemistry 2021 30: 115880. https://doi.org/10.1016/j.bmc.2020.115880. (IF 3,073).


Oscar A. Lenis-Rojas, M. Paula Robalo, Ana Isabel Tomaz,*Alexandra R. Fernandes,* Catarina Roma-Rodrigues, Ricardo G. Teixeira, Fernanda Marques, Mónica Folgueira, Julián Yáñez, Anabel Alba Gonzalez, Martín Salamini-Montemurri, Dawrin J. Pech Puch, Digna Vázquez-García, Margarita López Torres, Alberto Fernández and Jesús J. Fernández*. Half-sandwich Ru(p-cymene) compounds with diphosphanes: in vitro and in vivo evaluation as potential anticancer metallodrugs. Inorganic Chemistry 2020. https://dx.doi.org/10.1021/acs.inorgchem.0c02768. (IF 4,825).

Cinthia Alves-Barroco, João Paquete-Ferreira, Teresa Santos-Silva,*,Alexandra R. Fernandes,* Singularities of pyogenic streptococcal Biofilms – from formation to health implication. Frontiers in Microbiology 2020, 11:584947. doi: 10.3389/fmicb.2020.584947. (IF 4,235).

Catarina Roma-Rodrigues, Inês Pombo, Alexandra R. Fernandes* and Pedro V. Baptista* Hyperthermia Induced by Gold Nanoparticles and Visible Light Photothermy Combined with Chemotherapy to tackle doxorubicin sensitive and resistant colorectal Tumor 3D spheroids. Int. J. Mol. Sci. 2020, 21(21): 8017; https://doi.org/10.3390/ijms21218017 (IF 4,556). * Co-last and Corresponding authors

Alves-Barroco, C., Rivas-García, L.,Fernandes, A.R.*, Baptista, P.V.*. Tackling multidrug resistance in streptococci – from novel biotherapeutic strategies to nanomedicines. Frontiers in Microbiology 2020. https://doi.org/10.3389/fmicb.2020.579916 (IF 4,235).

Lilianne Beola, Laura Asín, Catarina Roma-Rodrigues, Yilian Fernández-Afonso, Raluca M. Fratila, David Serantes, Sergiu Ruta, Roy W. Chantrell,Alexandra R. Fernandes, Pedro V. Baptista, Jesús M. de la Fuente, Valeria Grazú, Lucía Gutiérrez. Intracellular number of magnetic nanoparticles modulates the apoptotic death pathway after magnetic hyperthermia treatment. ACS Appl. Mater. Interfaces 2020, 12, 39, 43474–43487. https://doi.org/10.1021/acsami.0c12900 (IF 8,758).

João Franco Machado, Diogo Sequeira, Fernanda Marques, M. Fátima M. Piedade, Maria J. Villa de Brito, M. Helena Garcia, Alexandra R. Fernandes*, Tânia S. Morais*. New copper(I) complexes selective for prostate cancer cells. Dalton Trans. 2020, https://doi.org/10.1039/D0DT02157A. (IF 4,174). Selected as TOP Paper

Daniela Ferreira, David Fontinha, Catarina Martins, David Pires,Alexandra R. Fernandes*, Pedro V. Baptista,* Gold nanoparticles for vectorization of nucleic acids towards cancer therapeutics. Molecules 2020, 25, 3489; doi:10.3390/molecules25153489. (IF 3,267).

Daniela Alves Ferreira, Luísa M.D.R.S. Martins, Alexandra R. Fernandes,* and Marta Martins*. A Tale of Two Ends: Repurposing Metallic Compounds from Anti-Tumour Agents to Effective Antibacterial Activity. Antibiotics (Basel) 2020, 9(6): 321. doi: 10.3390/antibiotics9060321 (IF 3,83).

Joanna Palion-Gazda, Luis R. Raposo, Katarzyna Choroba, Jacek E. Nycz, Ewa Malicka, Alina Bieńko, Agnieszka Lewińska, Karol Erfurt, Barbara Machura,* and  Alexandra R. Fernandes*. In vitro antiproliferative effect of Vanadium complexes bearing 8-hydroxyquinoline-based ligands: effect of vanadium oxidation state and ligand substitution pattern. Dalton Trans. 2020,49, 6596-6606. DOI: 10.1039/d0dt01017k (IF 4,174).

Gabriela Malta, Catarina Roma-Rodrigues, Daniela Peixoto, Luísa M. Ferreira, Pedro V. Baptista,Alexandra R. Fernandes*, and Paula S. Branco*. Synthesis of New Hetro-Arylidene-9(10H)-Anthrone Derivatives and biological evaluation as antiproliferative agents. Bioorganic Chemistry 2020, 99: 103849. DOI: 10.1016/j.bioorg.2020.103849 (IF 3,926).

Rita B. Restani, Rita F. Pires, Pedro V. Baptista,Alexandra R. Fernandes, Teresa Casimiro, Vasco D. B. Bonifácio, and Ana Aguiar-Ricardo. Nano-in-micro sildenafil dry powder formulations for the treatment of pulmonary arterial hypertension disorders: The synergic effect of POxylated polyurea dendrimers, PLGA and cholesterol. Part. Syst. Charact. 2020, 37, 1900447. DOI: 10.1002/ppsc.201900447 (IF 4,194).

Beatriz B Oliveira, Bruno Veigas,Alexandra R. Fernandes, Hugo Águas, Rodrigo Martins, Elvira Fortunato and Pedro Viana Baptista. Fast Prototyping Microfluidics: Integrating Droplet Digital Lamp for Absolute Quantification of Cancer Biomarkers. Sensors 2020, 20(6), 1624; https://doi.org/10.3390/s20061624. (IF 3,031).

Catarina Roma‐Rodrigues, Lorenzo Rivas‐García, Pedro V. Baptista* andAlexandra R. Fernandes*. Gene Therapy in Cancer Treatment: Why Go Nano? Pharmaceutics 2020, 12, 233; doi:10.3390/pharmaceutics12030233 (IF 4,773).

Mariana Bușilă, Aurel Tăbăcaru, Bogdan Ștefan Vasile, Ionela Andree Neacșu, Teresa Pinheiro, Catarina Roma-Rodrigues, Pedro V. Baptista, Alexandra R. Fernandes, António P. Matos, Fernanda Marques. Size-dependent biological activities of fluorescent organosilane-modified zinc oxide nanoparticles. J Biomed Nanotechnol. 2020 Feb 1;16(2):137-152. doi: 10.1166/jbn.2020.2882 (IF 5,068).

Nazanin Kordestani, Hadi Amiri Rudbari,*, Alexandra R. Fernandes*, Luís R. Raposo, Pedro V. Baptista, Daniela Ferreira, Giuseppe Bruno, Giovanni Bella, Scopelliti Rosario, David E. Herbert, Jason Braun. Mixed Ligand Copper(II) Complexes with Diimine Co-ligands: Effect of Coligand and Halogen bonding on the antiproliferative activities in human cancer cells.  ACS Comb. Sci. 2020, 22, 2, 89–99. https://doi.org/10.1021/acscombsci.9b00202 (IF 3.2).

Alexandra R. Fernandes*, Inês Martins, Marino F. A. Santos, Luís R. Raposo, Rita Mendes, Joana Marques, Carlos C. Romão, Maria João Romão, Teresa Santos-Silva*, Pedro V. Baptista*. Improving the anti-inflammatory response via Gold nanoparticles vectorization of CO-Releasing Molecules. ACS Biomater. Sci. Eng. 2020, 6, 2, 1090–1101. https://doi.org/10.1021/acsbiomaterials.9b01936 (IF 4.511).


Bilal Abdulmawjood, Catarina Roma-Rodrigues,Alexandra R. Fernandes*, Pedro V. Baptista*. LIQUID BIOPSIES IN MYELOID MALIGNANCIES. Cancer Drug Resist 2019;2:1044-1061. DOI.10.20517/cdr.2019.88.

Letícia Fialho, Diana Araújo, Vitor D. Alves, Catarina Roma-Rodrigues, Pedro V. Baptista,Alexandra R. Fernandes,*, Filomena Freitas,* Maria A. M. Reis. Cation-mediated gelation of the fucose-rich polysaccharide FucoPol: preparation and characterization of hydrogel beads and their cytotoxicity assessment. The International Journal of Polymeric Materials and Polymeric Biomaterials 2019. doi: 10.1080/00914037.2019.1695205. (IF 2.263).

Ana Amendoeira, Lorenzo Ribas, Alexandra R Fernandes, Pedro V. Baptista. Light irradiation of gold nanoparticles towards advanced cancer therapeutics. Advanced Therapeutics 2019. https://doi.org/10.1002/adtp.201900153.

Kuheli Das, Amitabha Datta, Yuh-Sheng Wen, Catarina Roma-Rodrigues, Luis R Raposo, Alexandra R. Fernandes* Chen-Hsiung Hung. Zn(II) and Co(II) derivatives anchored with scorpionate precursor: Antiproliferative evaluation in human cancer cell lines. Journal of Inorganic Biochemistry 2020, 202:110881; Doi.org/10.1016/j.jinorgbio.2019.110881 (IF 3.348).

Pedro Pedrosa, M. Luísa Corvo, Margarida Ferreira-Silva, Pedro Martins, Manuela Cola Carvalheiro, Pedro Costa, Carla Martins, Luísa Margarida Dias Ribeiro de Sousa Martins, Pedro Viana Baptista*, Alexandra Ramos Fernandes*. Targeting cancer resistance via multifunctional gold-nanoparticles. Int. J. Mol. Sci. 2019, 20, 5510; doi:10.3390/ijms20215510. (IF 4.183).

Manas Sutradhar, Elisabete C.B.A. Alegria, Francesco Ferretti, M. Fátima C. Guedes da Silva, Pedro V. Baptista,Alexandra R. Fernandes,* Armando J. L. Pombeiro. Antiproliferative activity of heterometallic sodium or potassium-dioxidovanadium(V) polymers. J Inorg Biochem. 2019 Nov;200:110811. doi: 10.1016/j.jinorgbio.2019.110811. (IF 3.348).

Katarzyna Choroba, Barbara Machura, Luis R. Raposo, Jan G. Małecki, Sławomir Kula, Michał Pająk, Karol Erfurt, Tomasz Pedzinski, Anna M. Maroń*,Alexandra R. Fernandes*. Platinum(II) complexes showing high cytotoxity toward A2780 ovarian carcinoma cells. Dalton Trans., 2019,48, 13081-13093. DOI: 10.1039/C9DT02894C (IF 4.099).

Katarzyna Choroba, Barbara Machura,* Slawomir Kula, Luis R. Raposo,Alexandra R. Fernandes,* Rafal Kruszynski, Karol Erfurt, Lidia S. Shul’pina, Yuriy N. Kozlov and Georgiy B. Shul’pin*. Copper(II) complexes with 2,2’:6’,2”-terpyridine, 2,6-di(thiazol-2-yl)pyridine and 2,6-di(pyrazin-2-yl)pyridine substituted with quinolines. Synthesis, structure, antiproliferative activity, and catalytic activity in oxidation of alkanes with peroxides. Dalton Transactions, 2019, DOI: 10.1039/C9DT01922G. (IF 4.099).

Catarina Roma-Rodrigues, Ines Pombo, Luis Raposo, Pedro Pedrosa, Alexandra R Fernandes and Pedro Viana Baptista*. Nanotheranostics targeting the tumor microenvironment. Front. Bioeng. Biotechnol. 7:197. doi: 10.3389/fbioe.2019.00197 (IF 5.122).

Catarina Roma-Rodrigues,Alexandra R. Fernandes*, Pedro V. Baptista*. Counteracting the effect of leukemia exosomes by antiangiogenic gold nanoparticles. International Journal of Nanomedicine 2019:14 6843–6854. DOI:10.2147/IJN.S215711 (IF 4.471).

Joana Almeida, Catarina Roma-Rodrigues, Pedro V. Baptista, Abdallah G. Mahmoud, M. Fátima C. Guedes da Silva, Armando J. L. Pombeiro andAlexandra R. Fernandes*. Structural characterization and biological properties of silver(I) tris(pyrazolyl)methane sulfonate. J. Inorganic Biochemistry 2019, 199:110789. Doi.org/10.1016/j.jinorgbio.2019.110789. (IF 3.348).

Catarina Bravo, M. Paula Robalo, Fernanda Marques,Alexandra R. Fernandes, Diogo A. Sequeira, M. Fátima M. Piedade, M. Helena Garcia, Maria J. Villa de Brito*, Tânia S. Morais*. First heterobimetallic Cu(I)–dppf complexes designed for anticancer applications: synthesis, structural characterization and cytotoxicity. New J of Chemistry 2019. DOI: 10.1039/c9nj02068c. (IF 3.062).

Kuheli Das, Amitabha Datta, Chiara Massera, Catarina Roma-Rodrigues, Mariana Barroso, Pedro V. Baptista andAlexandra R. Fernandes,* Structural aspects of a trimetallic CuII derivative: cytotoxicity and anti-proliferative activity on human cancer cell lines. J. Coord Chemistry 2019, 72(5-7):920–940. https://doi.org/10.1080/00958972.2019.1597973.

Bruno Veigas, Ana Matias, Tomás Calmeiro, Elvira Fortunato,Alexandra R. Fernandes and Pedro Viana Baptista. Antibody Modified Gold Nanoparticles for Fast Colorimetric screening of Rheumatoid arthritis. Analyst. 2019, 144(11):3613-3619. doi: 10.1039/c9an00319c.  (IF 3.864).

Ana R. Jesus, Mário R. C. Soromenho, Luís Raposo, José M. S. S. Esperança, Pedro V. Baptista,Alexandra R. Fernandes, and Patrícia M. Reis. Enhancement of the water solubility of paracetamol and sodium diclofenac with biocompatible N-acetyl amino acid N-alkyl cholinium-based ionic liquids. Eur J Pharm Biopharm. 2019, 137:227-232. doi: 10.1016/j.ejpb.2019.03.004. (IF 4.491).

Cinthia Alves-Barroco, Catarina Roma-Rodrigues, Natesan Balasubramanian, Marcia Aparecida Guimarães, Bernadete T. Ferreira-Carvalho, Jayaraman Muthukumaran, Daniela Nunes, Elvira Fortunato, Rodrigo Martins, Teresa Santos-Silva*, Agnes. M.S. Figueiredo*, Alexandra R. Fernandes*, Ilda Santos-Sanches. Biofilm development and computational screening for new putative inhibitors of a homolog of the regulatory protein BrpA in Streptococcus dysgalactiae subsp. dysgalactiae. International Journal of Medical Microbiology 2019. doi.org/10.1016/j.ijmm.2019.02.001. (IF 3.298).

Catarina Roma-Rodrigues, Rita Mendes, Pedro V. Baptista* and Alexandra R. Fernandes*. Targeting tumor microenvironment for cancer therapy. Int J Mol Sci. 2019, 20: E840. doi: 10.3390/ijms20040840. (IF 3.687).

Constantina Kourmentza, Diana Araujo, Chantal Servin, Catarina Roma-Rodriques, Joana Lia Ferreira, Madalena Dionisio, Filomena Freitas, Pedro V. Baptista, Alexandra R. Fernandes, Christian Grandfils, Maria A.M. Reis. Occurrence of non-toxic bioemulsifiers during polyhydroxyalkanoate production by Pseudomonas strains valorizing crude glycerol by-product. Bioresource Technology 2019, 281:31-40. doi.org/10.1016/j.biortech.2019.02.066. (IF 5.807).

Miguel M. Santos, Luís R. Raposo, Alexandra Costa, Pedro V. Baptista, Alexandra R. Fernandes*, Luís C. Branco*. Ionic Liquids and salts from Ibuprofen: Old drug, new properties. MedChemMed 2019. doi.org/10.1002/cmdc.201900040 (IF 2.3).

Manas Sutradhar, Alexandra R Fernandes,*, Fabiana Paradinha, Patricia Rijo, Catarina Garcia, Catarina Roma-Rodrigues, Armando J. L. Pombeiro, Adília Januário Charmier*. A new Cu(II)-O-Carvacrotinate Complex: synthesis, characterization and biological activity. J Inorganic Biochemistry 2019; 190:31-37. doi:10.1016/j.jinorgbio.2018.09.018 (IF 3.063).

Hélder Oliveira, Catarina Roma-Rodrigues, Ana Santos, Bruno Veigas, Ana Faria, Conceição Calhau, Victor de Freitas, Pedro V. Baptista, Nuno Mateus, Alexandra R. Fernandes, Iva Fernandes. GLUT1 and GLUT3 involvement in anthocyanin gastric transport - Nanobased targeted approach. Scientific Reports 2019. doi: 10.1038/s41598-018-37283-2 (IF 4.122).


Oscar A. Lenis-Rojas, M. Paula Robalob, Ana Isabel Tomaz*, Andreia Carvalho, Alexandra R. Fernandes*, Fernanda Marques, Mónica Folgueira, Julián Yáñez, Digna Vázquez-García, Margarita López Torres, Alberto Fernández, Jesús J. Fernández,*  RuII(p-cymene) compounds as effective and selective anticancer candidates with no toxicity in vivo. Inorg. Chem. 2018; 57:13150–13166. doi: 10.1021/acs.inorgchem.8b01270 (IF 4.7).

Raquel Vinhas, Patrícia Ribeiro, Alexandra Lourenço, Susana Santos, Marcos Lemos, Aida Botelho de Sousa, Pedro V. Baptista, Alexandra R. Fernandes*. A novel BCR-ABL1 mutation in a patient with Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia. Oncotargets and Therapy 2018; 2018:8589—8598. doi:10.2147/OTT.S177019 (IF 2.656).

Noora Svahn, Artur J. Moro, Catarina Roma-Rodrigues, Rakesh Puttreddy, Kari Rissanen, Pedro V. Baptista, Alexandra R. Fernandes*, João Carlos Lima, Laura Rodríguez*. The important role of the nuclearity, rigidity and solubility of phosphane ligands on the biological activity of gold(I) complexes. Chemistry – an European Journal 2018; 24:14654-14667. doi:10.1002/chem.201802547. (selected for cover) (IF 5.16).

Raquel Vinhas, Patrícia Ribeiro, Alexandra Lourenço, Susana Santos, Madalena Silva, Aida Botelho de Sousa, Pedro V. Baptista, Alexandra R. Fernandes*. A double Philadelphia chromosome-positive chronic myeloid leukemia patient, co-expressing P210BCR-ABL1 and P195BCR-ABL1 isoforms. Haematologica 2018; 103:e549-e552. doi:10.3324/haematol.2018.192534 (IF 9.09).

Pedro Pedrosa, Rita Mendes, Rita Cabral, Luisa Martins; Pedro V Baptista* and Alexandra R Fernandes*. Combination of chemotherapy and Au-nanoparticle photothermy in the visible to tackle drug resistance in cancer cells. Scientif Reports 2018; 8:11429. doi:10.1038/s41598-018-29870-0 (IF 4.122).

R. B. Restani, R. F. Pires, A Tomatcheva, Rita Cabral, Pedro V. Baptista, A. R. Fernandes, T. Casimiro, V. D. B. Bonifácio and A. Aguiar-Ricardo. Nano-in-micro engineered dry powder formulations for inhalation chemotherapy. Chemistry Open. 2018; 7:751-751. doi: 10.1002/open.201800093. (selected for cover) (IF 2.801).

Pedro V. Baptista*, Matthew P. McCusker, Andreia Carvalho, Daniela Alves Ferreira, Niamh Máire Mohan, Marta Martins* and Alexandra R. Fernandes*. Nano-Strategies to fight Multidrug Resistant Bacteria – “A battle of the titans”. Front Microbiol. 2018; 9:1441. doi: 10.3389/fmicb.2018.01441. eCollection 2018 (IF 4.076).

Kuheli Das, Belete B. Beyene, Amitabha Datta,*, Eugenio Garribb, Catarina Roma-Rodrigues, Ana Silva, Alexandra R. Fernandes*, Chen-Hsiung Hung*. EPR and Electrochemical Interpretation of Bispyrazolylacetate Anchored Ni(II) and Mn(II) Complexes: Cytotoxicity and Anti-proliferative Activity on Human Cancer Cell Lines. New J Chem. 2018; 42:9126-9139. doi:10.1039/C8NJ01033A (IF 3.201).

Anna Maroń, Katarzyna Czerwińska, Barbara Machura,*, Luis Raposo, Catarina Roma-Rodrigues, Alexandra R Fernandes,* Jan Grzegorz Małecki, Agata Szlapa-Kula, Slawomir Kula, Stanisław Krompiec. Spectroscopy, electrochemistry and antiproliferative properties of Au(III), Pt(II) and Cu(II) complexes bearing modified 2,2':6',2"-terpyridine ligands. Impact of metal center and substituent incorporated into terpy framework. Dalton Trans 2018; 47:6444-6463. doi:10.1039/C8DT00558C (IF 4.099).

Tânia S. Morais, Yann Jousseaume, M. Fátima M. Piedade, Catarina Roma-Rodrigues, Alexandra R. Fernandes, Fernanda Marques, Maria J. Villa de Brito, M. Helena Garcia. Important cytotoxic and cytostatic effects of new copper(I)–phosphane compounds with N,N, N,O and N,S bidentate ligands. Dalton Trans 2018; 47:7819-7829. doi: 10.1039/C8DT01653D (IF 4.099).

Chandramohan Bathula, Catarina Roma-Rodrigues, Alexandra R. Fernandes* and Subhabrata Sen*. Synthesis of tetrahydro-1H-indolo[2,3-b]pyrrolo[3,2-c]quinolones via intramolecular oxidative ring rearrangement of tetrahydro-β-carbolines and their biological evaluation. New J. Chem. 2018; 42:6538-6547. doi: 10.1039/C7NJ04616B (IF 3.201).

Cinthia Alves-Barroco, Catarina Roma-Rodrigues, Luís R. Raposo, Catarina Brás, Mário Diniz, João Caço, Pedro M. Costa, Ilda Santos-Sanches, Alexandra R. Fernandes*. Streptococcus dysgalactiae subsp. dysgalactiae isolated from milk of the bovine udder as emerging pathogens: in vitro and in vivo infection of human cells and zebrafish (Danio rerio) as biological models. MicrobiologyOpen 2018 Mar 25:e00623. doi: 10.1002/mbo3.623 (IF 2.682).

A.P.C. Ribeiro, S. Anbu, E.C.B.A. Alegria, A.R. Fernandes, P.V. Baptista, R. Mendes, A.S. Santos, M. Mendes, M.F.C. Guedes da Silva, A.J.L. Pombeiro. Cell Cytotoxicity, DNA/BSA binding of green-synthesized silver nanoparticles. Biomed Pharmacother 2018; 101:137-144. doi: 10.1016/j.biopha.2018.02.069 (IF 3.452).

Gomes S.E., Pereira D.M., Roma-Rodrigues C., Fernandes A.R.*, Borralho P.M.B., Rodrigues C.M.P.*. Proteomic analysis of HCT116 colon cancer cells overexpressing miR-143 and miR-145. PLoS ONE 2018; 13(1): e0191607. DOI. 10.1371/journal.pone.0191607 (IF 2.766).

Ana Sofia Matias, Raquel Vinhas, Rita Mendes, Alexandra R. Fernandes and Pedro V Baptista. Nanoparticles as emerging diagnostic tools in liquid tumours. European Medical J Innov. 2018;2[1]:80-87.

Peixoto, Daniela; Figueiredo, Margarida; Malta, Gabriela; Roma-Rodrigues, Catarina; Baptista, Pedro; Fernandes, Alexandra R; Barroso, Sónia; Carvalho, Ana Luisa; Afonso, Carlos; Ferreira, Luisa; Branco, Paula. Synthesis, cytotoxicity evaluation in human cell lines and in vitro DNA interaction of a hetero arylidene-9,10-anthrone. European Journal of Organic Chemistry. 2018; 2018(4):545-549. DOI 10.1002/ejoc.201701500 (IF 2.822).

Pedro Urbano Alves, Raquel Vinhas, Alexandra R. Fernandes, Semra Zuhal Birol, Levent Trabzon, Iwona Bernacka-Wojcik, Rui Igreja, Paulo Lopes, Pedro Viana Baptista, Hugo Águas, Elvira Fortunato, Rodrigo Martins. Multifunctional microfluidic chip for gold nanoprobe based RNA detection with built-in passive micromixer and optical detection modules – application to Chronic Myeloid Leukemia. Scientific Reports 2018; 8:381. DOI:10.1038/s41598-017-18725-9 (IF 4.122).



Raquel Vinhas, Rita Mendes, Alexandra R. Fernandes, Pedro V. Baptista*. Nanoparticles – Emerging potential for managing leukemia and lymphoma. Bioeng. Biotechnol., Front Bioeng Biotechnol. 2017;5:79. doi: 10.3389/fbioe.2017.00079. eCollection 2017.

Pedro Pedrosa, Amelie Heuer-Jungemann, Antonios G. Kanaras, Alexandra R. Fernandes and Pedro V. Baptista*. Potentiating angiogenesis arrest in vivo via laser irradiation of peptide functionalised gold nanoparticles. J Nanobiotechnology 2017; 15: 85.

Rita Mendes, Pedro Pedrosa, João C. Lima, Alexandra R. Fernandes*, Pedro V. Baptista*. Photothermal enhancement of chemotherapy in breast cancer by visible irradiation of Gold Nanoparticles. Scientific Reports 2017, 7, 10872. doi:10.1038/s41598-017-11491-8.

Joana R. Sousa, Célia M. Silveira, Catarina Roma-Rodrigues, Alexandra R. Fernandes, Bart Devreese, Isabel Moura, José J.G. Moura, M. Gabriela Almeida,*. Understanding the response of Desulfovibrio desulfuricans ATCC 27774 to different electron acceptors - biosynthetic costs modulate substrate selection. BBA - Proteins and Proteomics 2017 Nov;1865(11 Pt A):1455-1469. doi: 10.1016/j.bbapap.2017.07.021.

Luiz Gonzaga do Nascimento-Netoa, Maria Guadalupe Cabral, Rômulo Farias Carneiro, Francisco Vassiliepe Sousa Arruda, Zélia Silva, Celso Shiniti Nagano, Alexandra R Fernandes, Alexandre Holanda Sampaio, Edson Holanda Teixeira and Paula Alexandra Videira. Halilectin-3, a lectin from the marine sponge Haliclona caerulea, induces apoptosis and autophagy in human breast cancer MCF7 cells through a caspase-9 and LC3 pathway. Anti-Cancer Agents in Medicinal Chemistry 2017, Nov 13. doi: 10.2174/1871520617666171114094847.

Katarzyna Czerwinska, Barbara Machura* Slawomir Kula, Stanislaw Krompiec, Catarina Roma-Rodrigues, Alexandra R. Fernandes*, Lidia S. Shul’pina and Georgiy B. Shul’pin*. Copper(II) complexes of functionalized 2,2':6',2''-terpyridines and 2,6-di(thiazol-2-yl)pyridine: structure, spectroscopy, cytotoxicity and catalytic activity. Dalton Trans. 2017 Jul 25;46(29):9591-9604. doi: 10.1039/c7dt01244f..

Manas Sutradhar,* Rajeshwari, Tannistha Roy Barman, Alexandra R Fernandes* Fabiana Paradinha, Catarina Roma-Rodrigues, M. Fátima C. Guedes da Silva, and Armando J. L. Pombeiro*. Mixed ligand aroylhydrazone and N-donor heterocyclic Lewis base Cu(II) complexes as potential antiproliferative agents. J Inorg Biochem 2017 Oct;175:267-275. doi: 10.1016/j.jinorgbio.2017.07.034.

Márcia Tavares, Renato P. Cabral, Clarinda Costa, Pedro Martins, Alexandra R. Fernandes, Teresa Casimiro, Ana Aguiar-Ricardo. Development of PLGA dry powder microparticles by supercritical CO2-assisted spray-drying for potential vaccine delivery to the lungs. The Journal of Supercritical Fluids 2017; 128: 235-243.

Oscar A. Lenis-Rojas, Catarina Roma-Rodrigues, Alexandra R. Fernandes*, Fernanda Marques, David Pérez-Fernández, Jorge Guerra-Varela, Laura Sánchez, Digna Vázquez-García, Margarita López Torres, Alberto Fernández, Jesús J. Fernández*. Dinuclear RuII(bipy)2 Derivatives: Structural, Biological and In Vivo Zebrafish Toxicity Evaluation. Inorganic Chemistry 2017. 56 (12), pp 7127–7144.

Alexandra R. Fernandes*, João Jesus, Pedro Martins, Sara Figueiredo, Daniela Rosa, Luísa M.R.D.R.S. Martins, Maria Luísa Corvo, Manuela C. Carvalheiro, Pedro M. Costa, Pedro V. Baptista*. Multifunctional gold-nanoparticles: a nanovectorization tool for the targeted delivery of novel chemotherapeutic agents. Journal of Control Release 2017, 245:52-61. doi.org/10.1016/j.jconrel.2016.11.021.

Raquel Vinhas, Alexandra R. Fernandes*, Pedro V. Baptista*. Gold nanoparticles for BCR-ABL1 gene silencing – Improving tyrosine kinase inhibitors efficacy in chronic myeloid leukemia. Mol Ther Nucleic Acids. 2017, 7:408-416. doi.org/10.1016/j.omtn.2017.05.003.

Rita Mendes, Alexandra R. Fernandes* and Pedro V. Baptista*. Gold nanoparticle approach to the selective delivery of gene silencing in cancer – the case for combined delivery? Clinical Genomics in Genetic Diseases and Cancer. Genes 2017, 8:94.

Catarina Roma-Rodrigues, Francisca Pereira, António P. Alves de Matos, Marta Fernandes, Pedro V. Baptista,* AND Alexandra R. Fernandes,* Smuggling gold nanoparticles across cell types – a new role for exosomes in gene silencing. Nanomedicine. 2017 Jan 28;13(4):1389-1398.

Catarina Roma-Rodrigues, Luís R. Raposo, Rita Cabral, Fabiana Paradinha, Pedro V Baptista* AND Alexandra R Fernandes*. Tumor microenvironment modulation via gold nanoparticles targeting malicious exosomes: implications in cancer diagnostics and therapy. Int J Mol Sci. 2017 Jan 14;18(1).

Luís R. Raposo, Catarina Roma-Rodrigues, João Jesus, Luísa M.D.R.S. Martins, Armando J Pombeiro, Pedro V. Baptista*, Alexandra R. Fernandes*. Targeting canine mammary tumors via gold nanoparticles functionalized with promising Co(II) and Zn(II) compounds. Veterinary and Comparative Oncology 2017; 1–6.

Milton Cordeiro, Lara Carvalho, Joana Filipa Silva, Leonor Saúde, Alexandra R Fernandes, Pedro V. Baptista *. Gold nanobeacons for tracking gene silencing in zebrafish. Nanomaterials (Basel). 2017 Jan 11;7(1).