Ana Rita Grosso

Professor Auxilar

Interesses Científicos

Computational Biomedicine Research: My mission is to understand the (epi)genome biology and its impact on cancer and other diseases using computational multi-omics approaches. Such methods rely on the statistical analysis and integration of large-scale data (high-throughput sequencing, microarrays, proteomics, high-throughput screening) and clinical/phenotypic data. _____________________________________________________________________________________________________ Computational Biology/Bioinformatics Training: I would like to boost the computational biology field, which is rapidly evolving both in terms of breadth of scope of applications and depth of what can be accomplished. However, there is a big demand for bioinformatics skills in research. I have been disseminating such specialized knowledge by teaching MSc courses, training MSc and PhD students, and promoting dedicated seminars among young and senior researchers.

Publicações Representativas

Sobral D, Martins M, Kaplan S, Golkaram M, Salmans M, Khan N, Vijayaraghavan R, Casimiro S, Fernandes A, Borralho P, Ferreira C, Pinto R, Abreu C, Costa AL, Zhang S, Pawlowski T, Godsey J, Mansinho A, Macedo D, Lobo-Martins S, Filipe P, Esteves R, Coutinho J, Costa PM, Ramires A, Aldeia F, Quintela A, So A, Liu L, Grosso AR, Costa L. (2022) Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal cancer evolution and metastatic development. Commun Biol. 2022 Sep 9;5(1):937. URL
Sobral D, Francisco R, Duro L, Videira PA, Grosso AR. (2022) Concerted Regulation of Glycosylation Factors Sustains Tissue Identity and Function. Biomedicines. 10(8):1805. URL
Andrade J, Shi C, Costa ASH, Choi J, Kim J, Doddaballapur A, Sugino T, Ong YT, Castro M, Zimmermann B, Kaulich M, Guenther S, Wilhelm K, Kubota Y, Braun T, Koh GY, Grosso AR, Frezza C, Potente M. (2021) Control of endothelial quiescence by FOXO-regulated metabolitesNature Cell Biology, 23(4):413-423. URL
Povoa V, Almeida CR, Maia-Gil M, Sobral D, Domingues M, Martinez-Lopez M, Fuzeta MA, Silva C, Grosso AR, Fior R (2021) Innate immune evasion revealed in a colorectal zebrafish xenograft model, Nature Communications, 12(1156).  URL
Pinto R, Sobral D, Grosso AR (2021) Comprehensive Detection of Pseudogenes Transcribed by Readthrough. In Poliseno L. (Ed) Pseudogenes: Functions and Protocols, Humana Press, New York, NY, pp. 85-102, Online ISBN: 978-1-0716-1503-4 URL
Matos MR, Posa I, Carvalho FS, Morais VA, Grosso AR, de Almeida SF. (2019) A Systematic Pan-Cancer Analysis of Genetic Heterogeneity Reveals Associations with Epigenetic Modifiers. Cancers, 11 (3), DOI: 10.3390/cancers11030391
Posa, I; Carvalho, S; Tavares, J; Grosso, AR. 2016. A pan-cancer analysis of MYC-PVT1 reveals CNV-unmediated deregulation and poor prognosis in renal carcinoma. Oncotarget, 7(30), DOI: 10.18632/oncotarget.9487
Nojima T, Gomes T, Grosso ARF, Kimura H, Dye MJ, Dhir S, Carmo-Fonseca M, Proudfoot NJ.. 2015. Mammalian NET-Seq Reveals Genome-wide Nascent Transcription Coupled to RNA Processing. CELL, 161(3), DOI: 10.1016/j.cell.2015.03.027
Grosso, AR; Leite, AP; Carvalho, S; Matos, MR; Martins, FB; Vítor, AC; Desterro, JMP; Carmo-Fonseca, M; de Almeida, SF. 2015. Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma. eLife, 4(NOVEMBER2015), DOI: 10.7554/eLife.09214


Computational Multi-Omics Lab